Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan
|Corresponding Author||Wang，Xianghui; Deng，Hongping; Xu，Min|
Commercial gadolinium (Gd)-based contrast agents (GBCAs) play important role in clinical diagnostic of hepatocellular carcinoma, but their diagnostic efficacy remained improved. As small molecules, the imaging contrast and window of GBCAs is limited by low liver targeting and retention. Herein, we developed a liver-targeting gadolinium (Ⅲ) chelated macromolecular MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan, namely, CS-Ga-(Gd-DTPA), to improve hepatocyte uptake and liver retention. Compared to Gd-DTPA and non-specific macromolecular agent CS-(Gd-DTPA), CS-Ga-(Gd-DTPA) showed higher hepatocyte uptake, excellent cell and blood biocompatibility in vitro. Furthermore, CS-Ga-(Gd-DTPA) also exhibited higher relaxivity in vitro, prolonged retention and better T1-weighted signal enhancement in liver. At 10 days post-injection of CS-Ga-(Gd-DTPA) at a dose of 0.03 mM Gd/Kg, Gd had a little accumulation in liver with no liver function damage. The good performance of CS-Ga-(Gd-DTPA) gives great confidence in developing liver-specifc MRI contrast agents for clinical translation.
National Natural Science Foundation of China["82204505","21875068"] ; Natural Science Foundation of Shanghai[19ZR1438300]
|WOS Research Area|
Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
1.Shanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,China
2.Shanghai Key Laboratory of Magnetic Resonance,School of Physics and Electronic Science,East China Normal University,Shanghai,China
3.Southern University of Science and Technology,Shenzhen,China
4.Department of Stomatology,Shanghai 8th People’s Hospital,Shanghai,China
Xu，Li,Ren，Zhanying,Li，Guolin,et al. Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan[J]. Frontiers in Bioengineering and Biotechnology,2023,11.
Xu，Li.,Ren，Zhanying.,Li，Guolin.,Xu，Danni.,Miao，Jiaqian.,...&Xu，Min.(2023).Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan.Frontiers in Bioengineering and Biotechnology,11.
Xu，Li,et al."Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan".Frontiers in Bioengineering and Biotechnology 11(2023).
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