Nanomaterials for miRNA detection: The hybridization chain reaction strategy

Mohan，Brij1; Kumar，Sandeep2; Kumar，Suresh3; Modi，Krunal4; Tyagi，Deependra5; Papukashvili，Dimitri5; Rcheulishvili，Nino5; Pombeiro，Armando J.L.1

2023

10.1039/d2sd00209d

Sensors and Diagnostics   Impact Factor & Quartile

2635-0998

MicroRNAs (miRNAs) with nucleotides are a class of endogenous small RNAs and can play crucial functions in diagnosing diseases. In particular, the group of miRNAs is responsible for information related to the cell and disease. Among various techniques for miRNA detection, the hybridization chain reaction (HCR) strategy shows potential and efficiency. This review summarizes and studies the most efficient HCR strategy for detecting miRNA using nanomaterials due to their ultrasensitive detection and excellent performances. In addition, signal amplification for the sensitive detection of miRNA due to the chain reaction has been studied. The key factors, such as limit of detection (LOD), linear range, the importance of the strategy, limitations or challenges, and future perspective are described. Finally, the study will provide new findings for developing a miRNA detection strategy applicable to disease diagnosis.

English

Others

2-s2.0-85159243764

Scopus

1.Centro de Química Estrutural,Institute of Molecular Sciences,Instituto Superior Técnico,Universidade de Lisboa,Lisboa,Av. Rovisco Pais,1049-001,Portugal
2.School of Science,Harbin Institute of Technology (Shenzhen),Shenzhen,518055,China
3.Department of Chemistry,SUS Government PG College,Karnal,Matak Majri, Haryana,132041,India
4.Department of Humanity and Science,School of Engineering,Indrashil University,Mehsana,Gujarat,382740,India
5.Southern University of Science and Technology,Shenzhen,518000,China

Mohan，Brij,Kumar，Sandeep,Kumar，Suresh,et al. Nanomaterials for miRNA detection: The hybridization chain reaction strategy[J]. Sensors and Diagnostics,2023,2(1):78-89.

Mohan，Brij.,Kumar，Sandeep.,Kumar，Suresh.,Modi，Krunal.,Tyagi，Deependra.,...&Pombeiro，Armando J.L..(2023).Nanomaterials for miRNA detection: The hybridization chain reaction strategy.Sensors and Diagnostics,2(1),78-89.

Mohan，Brij,et al."Nanomaterials for miRNA detection: The hybridization chain reaction strategy".Sensors and Diagnostics 2.1(2023):78-89.