Novel photodynamic therapy using two-dimensional NiPS3nanosheets that target hypoxic microenvironments for precise cancer treatment

Wu，Zongze1; Liu，Quan1; Wageh，Swelm3; Sun，Zhe1; Al-Hartomy，Omar A.3; Al-Sehemi，Abdullah G.4,5; Yan，Lesen1; Chen，Jiaojuan1; Zhang，Wenjian1; Yang，Jilin1; Zhang，Han2; Liu，Liping1

2023

10.1515/nanoph-2022-0520

Nanophotonics   Impact Factor & Quartile

2192-8606

2192-8614

Photodynamic therapy (PDT) is a highly promising modality against cancer, but its efficacy is severely limited by the low oxygen content in solid tumors. In this study, a smart photosensitive NiPS3 nanosheet was developed to solve the problem of low oxygen to allow PDT to be performed against tumors. The photosensitized ROS generation mechanism of NiPS3 is the photon-generated electron-hole pathway, which can generate O2·- and ·OH at the conduction band and valance band, respectively. More crucial is that ·OH generation doesn't need O2, and the O2·- can also work in a low O2 environment, and depleting oxygen in tumor cells. Modified with triphenylphosphine (TPP) and based on density functional theory (DFT) calculations and experimental data, the NiPS3@TPP nano-system underwent targeted action toward mitochondria. In vitro experiments demonstrated that the reactive oxygen species (ROS) produced by NiPS3@TPP altered mitochondrial membrane permeability, which not only prolonged the PDT effect but also resulted in mitochondria apoptosis pathways inducing an apoptosis cascade. In vivo experiments demonstrated the targeting capability with low toxicity of the NiPS3@TPP nano-system. Tumor targeting at the tested dose indicated that it represented a promising biocompatible photosensitizer for in vivo biomedical applications.

mitochondria NiPS3 photodynamic therapy photosensitizer ROS

SCI

English

First ; Corresponding

Science and Technology Innovation Commission of Shenzhen[JCYJ20190806160412946] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515220059] ; Shenzhen Key Medical Discipline Construction Fund[SZXK015] ; King Khalid University through Research Center for Advanced Materials Science (RCAMS)[RCAMS/KKU/009/21] ; Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia[IFPDP-236-22]

Science & Technology - Other Topics ; Materials Science ; Optics ; Physics

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Optics ; Physics, Applied

WOS:000911026900001

WALTER DE GRUYTER GMBH

2-s2.0-85143741394

Scopus

1.Division of Hepatobiliary and Pancreas Surgery,Department of General Surgery,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
2.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Physics and Optoelectronic Engineering,Otolaryngology Department,Biobank of the First Affiliated Hospital,Health Science Center,Shenzhen Second People's Hospital,Shenzhen University,Shenzhen,Guangdong,518060,China
3.Department of Physics,Faculty of Science,King Abdulaziz University,Jeddah,21589,Saudi Arabia
4.Research Center for Advanced Materials Science (RCAMS),King Khalid University,Abha,P.O. Box 9004,61413,Saudi Arabia
5.Department of Chemistry,College of Science,King Khalid University,Abha,P.O. Box 9004,61413,Saudi Arabia

Wu，Zongze,Liu，Quan,Wageh，Swelm,et al. Novel photodynamic therapy using two-dimensional NiPS3nanosheets that target hypoxic microenvironments for precise cancer treatment[J]. Nanophotonics,2023,12(1):81-98.

Wu，Zongze.,Liu，Quan.,Wageh，Swelm.,Sun，Zhe.,Al-Hartomy，Omar A..,...&Liu，Liping.(2023).Novel photodynamic therapy using two-dimensional NiPS3nanosheets that target hypoxic microenvironments for precise cancer treatment.Nanophotonics,12(1),81-98.

Wu，Zongze,et al."Novel photodynamic therapy using two-dimensional NiPS3nanosheets that target hypoxic microenvironments for precise cancer treatment".Nanophotonics 12.1(2023):81-98.