Electromechanical Coupling in Collagen Measured under Increasing Relative Humidity

Bazaid, Arwa1,2; Zhang, Fengyuan1,2,6; Zhang, Qiancheng1,2; Neumayer, Sabine1,2,7; Denning, Denise3; Habelitz, Stefan4; Ferreira, Ana Marina5; Rodriguez, Brian J.1,2

2023-09-01

10.3390/ma16176034

MATERIALS   Impact Factor & Quartile

1996-1944

The functional role of collagen piezoelectricity has been under debate since the discovery of piezoelectricity in bone in 1957. The possibility that piezoelectricity plays a role in bone remodeling has generated interest in the investigation of this effect in relevant physiological conditions; however, there are conflicting reports as to whether collagen is piezoelectric in a humid environment. In macroscale measurements, the piezoelectricity in hydrated tendon has been shown to be insignificant compared to dehydrated tendon, whereas, at the nanoscale, the piezoelectric effect has been observed in both dry and wet bone using piezoresponse force microscopy (PFM). In this work, the electromechanical properties of type I collagen from a rat tail tendon have been investigated at the nanoscale as a function of humidity using lateral PFM (LPFM) for the first time. The relative humidity (RH) was varied from 10% to 70%, allowing the piezoelectric behavior to be studied dry, humid, as well as in the hydrated range for collagen in physiological bone (12% moisture content, corresponding to 40-50% RH). The results show that collagen piezoresponse can be measured across the humidity range studied, suggesting that piezoelectricity remains a property of collagen at a biologically relevant humidity.

collagen piezoelectricity atomic force microscopy piezoresponse force microscopy mechanotransduction humidity

SCI

English

Others

Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics

Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Physics, Applied ; Physics, Condensed Matter

WOS:001062124800001

MDPI

Web of Science

1.Univ Coll Dublin, Sch Phys, Dublin D04 V1W8, Ireland
2.Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin D04 V1W8, Ireland
3.Technol Univ Dublin, FOCAS Res Inst, City Campus, Dublin D04 V1W8, Ireland
4.Univ Calif San Francisco, Sch Dent, Dept Preventat & Restorat Dent Sci, San Francisco, CA 94143 USA
5.Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, England
6.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
7.Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA

Bazaid, Arwa,Zhang, Fengyuan,Zhang, Qiancheng,et al. Electromechanical Coupling in Collagen Measured under Increasing Relative Humidity[J]. MATERIALS,2023,16(17).

Bazaid, Arwa.,Zhang, Fengyuan.,Zhang, Qiancheng.,Neumayer, Sabine.,Denning, Denise.,...&Rodriguez, Brian J..(2023).Electromechanical Coupling in Collagen Measured under Increasing Relative Humidity.MATERIALS,16(17).

Bazaid, Arwa,et al."Electromechanical Coupling in Collagen Measured under Increasing Relative Humidity".MATERIALS 16.17(2023).