Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction

Zhou, Dan1,2; Ye, Zhongwen3; Nie, Zhiqiang4; Chen, Chaolei4; Luo, Songyuan4; Yan, Mengqi4; Wang, Jiabin5; Feng, Yingqing4,6

2023-09-01

10.1111/1753-0407.13478

JOURNAL OF DIABETES   Impact Factor & Quartile

1753-0393

1753-0407

["ObjectiveThis study aims to explore the association between metabolic syndrome (MetS) and left ventricular diastolic dysfunction (LVDD) and systolic dysfunction (LVSD), defined by impaired global longitudinal strain (GLS), and assess additive and multiplicative interactions among age, sex, obesity, and MetS regarding LVDD and LVSD.MethodsWe prospectively recruited 5503 participants from the China PEACE (Patient-Centered Evaluative Assessment of Cardiac Events) Million Persons Project with complete echocardiography exam. Multivariable logistic models were used to calculate adjusted odds ratios to evaluate both additive and multiplicative interactions.ResultsThe mean age was 56.59 years; 59.4% were women, 46.7% had MetS, 26.6% had left ventricular hypertrophy, 46.3% had LVDD, and 12.50% had impaired GLS. Compared to the non-MetS, the odds ratio (OR) of LVDD and impaired GLS in MetS were 1.40 (1.20-1.64) and 1.26 (1.03-1.54), respectively. For LVDD, relative excess risk due to additive interaction (RERI) for women and MetS, elderly and MetS, obesity and MetS were 0.76 (0.02-1.50), 35.65 (17.51-53.79), and 2.14 (0.66-3.62), respectively, thus suggesting additive interactions. For impaired GLS, RERI for obesity and MetS was 3.37 (0.50-6.24), thus suggesting additive interactions.ConclusionsThe MetS is independently associated with LVDD and impaired GLS. From the public health implications, prevention of MetS in women, elderly, and obese individuals might result in a greater reduction of LVDD and LVSD risk in cardiovascular high-risk population.","HighlightsLeft ventricular dysfunction such as left ventricular diastolic dysfunction (LVDD) and impaired global longitudinal strain (GLS) were important causes of cardiac events in cardiovascular high-risk population.Metabolic disorders play a key role in the progression of left ventricular dysfunction, therefore, the prevention of metabolic syndrome (MetS) in women, elderly, and obese individuals might reduce the burden of LVDD and left ventricular systolic dysfunction.The study first analyzed LVDD and GLS by echocardiography in a large community population, providing new insights for community target organ damage screening in MetS.image"]

global longitudinal strain interaction effect left ventricular dysfunction metabolic syndrome

SCI

English

Others

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:001068934700001

WILEY

Web of Science

1.Jinan Univ, Dept Internal Med, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
3.Zhuhai Ctr Dis Control & Prevent, Zhuhai, Peoples R China
4.Southern Med Univ, Dept Cardiol, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangdong Cardiovasc Inst,Guangdong Prov Peoples H, Guangzhou, Peoples R China
5.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Global Hlth Res Ctr, Guangzhou, Peoples R China
6.Southern Med Univ, Dept Cardiol, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp,Guangdong Acad Med Sci, 106 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China

Zhou, Dan,Ye, Zhongwen,Nie, Zhiqiang,et al. Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction[J]. JOURNAL OF DIABETES,2023.

Zhou, Dan.,Ye, Zhongwen.,Nie, Zhiqiang.,Chen, Chaolei.,Luo, Songyuan.,...&Feng, Yingqing.(2023).Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction.JOURNAL OF DIABETES.

Zhou, Dan,et al."Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction".JOURNAL OF DIABETES (2023).