| Title | Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation |
| Author | |
| Corresponding Author | Chen, Gen-Qiang; Zhang, Xumu |
| Publication Years | 2023-09-01
|
| DOI | |
| Source Title | |
| ISSN | 1523-7060
|
| EISSN | 1523-7052
|
| Abstract | Chlorohydrins and oxaheterocycles are synthetically valuable building blocks for diverse natural products and therapeutic substances. A highly efficient Ir/f-phamidol-catalyzed asymmetric hydrogenation of ?-chloroketones was successfully developed, and various chlorohydrins and oxaheterocycles were obtained divergently with excellent yields and enantioselectivities (up to >99% yield and >99% ee). Synthetic utilities of this divergent transformation were demonstrated by gram-scale synthesis of key intermediates of several enantiomerically enriched drugs via this catalytic methodology. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Key R&D Program of China[2021YFA1500201]
; Shenzhen Science and Technology Innovation Committee["KQTD20150717103157174","JCYJ20210324104202007"]
; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002]
; Key-Area Research and Development Program of Guangdong Province[2020B010188001]
; Innovative Team of Universities in Guangdong Province[2020KCXTD016]
; National Natural Science Foundation of China["21991113","21901107","22171129"]
; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055]
; China Postdoctoral Science Foundation[2023M731516]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:001066346500001
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/571835 |
| Department | Department of Chemistry 前沿与交叉科学研究院 |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Chem, Shenzhen Key Lab Small Mol Drug Discovery & Synth, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Med Pingshan, Shenzhen 518000, Peoples R China 3.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518000, Peoples R China |
| First Author Affilication | Department of Chemistry; Southern University of Science and Technology |
| Corresponding Author Affilication | Department of Chemistry; Southern University of Science and Technology; Academy for Advanced Interdisciplinary Studies |
| First Author's First Affilication | Department of Chemistry |
| Recommended Citation GB/T 7714 |
Zong, Yan,Zou, Xiaomei,Song, Jingyuan,et al. Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation[J]. ORGANIC LETTERS,2023.
|
| APA |
Zong, Yan,Zou, Xiaomei,Song, Jingyuan,Chen, Gen-Qiang,&Zhang, Xumu.(2023).Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation.ORGANIC LETTERS.
|
| MLA |
Zong, Yan,et al."Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation".ORGANIC LETTERS (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
;
Edit Comment