| Title | Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma |
| Author | |
| Corresponding Author | Liu, Fanna; Tang, Donge; Dai, Yong |
| Publication Years | 2023-09-23
|
| DOI | |
| Source Title | |
| EISSN | 1477-7819
|
| Volume | 21Issue:1 |
| Abstract | PurposeOral adenoid cystic carcinoma (OACC) has high rates of both local-regional recurrence and distant metastasis. The objective of this study is to investigate the impact of Khib on OACC and its potential as a targeted therapeutic intervention.Experimental designWe investigated the DEPs (differentially expressed proteins) and DHMPs between OACC-T and OACC-N using LC-MS/MS-based quantitative proteomics and using several bioinformatics methods, including GO enrichment analysis, KEGG pathway analysis, subcellular localization prediction, MEA (motif enrichment analysis), and PPI (protein-protein interaction networks) to illustrate how Khib modification interfere with OACC evolution.ResultsCompared OACC-tumor samples (OACC-T) with the adjacent normal samples (OACC-N), there were 3243 of the DEPs and 2011 Khib sites were identified on 764 proteins (DHMPs). DEPs and DHMPs were strongly associated to glycolysis pathway. GAPDH of K254, ENO of K228, and PGK1 of K323 were modified by Khib in OACC-T. Khib may increase the catalytic efficiency to promote glycolysis pathway and favor OACC progression.Conclusions and clinical relevanceKhib may play a significant role in the mechanism of OACC progression by influencing the enzyme activity of the glycolysis pathway. These findings may provide new therapeutic options of OACC. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| WOS Research Area | Oncology
; Surgery
|
| WOS Subject | Oncology
; Surgery
|
| WOS Accession No | WOS:001071068400002
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/571864 |
| Affiliation | 1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Clin Med Res Ctr, Shenzhen 518020, Guangdong, Peoples R China 2.Jinan Univ, Affiliated Hosp 1, Nephrol Dept, Guangzhou 510632, Peoples R China 3.Shenzhen Pingle Orthoped Hosp, Shenzhen Pingshan Tradit Chinese Med Hosp, Expt Ctr, Shenzhen 518118, Guangdong, Peoples R China 4.Jinan Univ, Dept Oral & Maxillofacial Surg, Shenzhen Peoples Hosp, Clin Med Coll 2,Stomatol Med Ctr, Shenzhen 518020, Peoples R China 5.Southern Univ Sci & Technol, Taizhou Res Inst, Comprehens Hlth Ind Res Ctr, Taizhou 318000, Peoples R China 6.924 Hosp PLA Joint Logist Support Force, Dept Organ Transplantat, Med Qual Specialty Joint Logist Support Force, Guilin 541002, Peoples R China 7.Anhui Univ Sci & Technol, Affiliated Hosp 1, Sch Med, Huainan 232001, Anhui, Peoples R China |
| Corresponding Author Affilication | Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
Chen, Sining,Li, Dandan,Zeng, Zhipeng,et al. Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2023,21(1).
|
| APA |
Chen, Sining.,Li, Dandan.,Zeng, Zhipeng.,Zhang, Wei.,Xie, Hongliang.,...&Dai, Yong.(2023).Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma.WORLD JOURNAL OF SURGICAL ONCOLOGY,21(1).
|
| MLA |
Chen, Sining,et al."Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma".WORLD JOURNAL OF SURGICAL ONCOLOGY 21.1(2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
;
Edit Comment