The association of handgrip strength with all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination Survey database prospective cohort study with propensity score matching

Xiong, Lijiao1,2; Zeng, Zhaohao2,3; Wang, Shuojia1,2,4; Liao, Tingfeng1,2; Wang, Xiaohao1,2; Wang, Xinyu1,2; Yang, Guangyan1,2; Li, Yanchun1,2; Li, Lixing1,2; Zhu, Jing1,2; Zhao, Pengfei1,2; Yang, Shu1,2; Kang, Lin1,2; Liang, Zhen1,2

2023-09-15

10.3389/fnut.2023.1183973

FRONTIERS IN NUTRITION   Impact Factor & Quartile

2296-861X

Objective: To investigate the association between handgrip strength (HGS) with all-cause and cardiovascular disease (CVD) mortality in US adults.Method: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) prospective cohort study (2011-2014) with 10,470 participants. The cox regression analysis, Kaplan-Meier survival curves, fitted curves, ROC curves, and propensity score-matched analysis (PSM) with inverse probability of treatment weighting (IPTW), SMRW (PSM with repeated weights), PA (pairwise algorithm), and OW (overlap weighting) regression analysis were performed to assess the relationship between HGS and all-cause and CVD mortality.Results: The low HGSs (men <37.4 kg, women <24 kg), was found to be associated with higher all-cause and CVD mortality in a reverse J-shaped curve (p < 0.05). Adjusting for multiple covariates including age, BMI, race, education level, marriage status, smoking and alcohol use, and various comorbidities, the hazard ratio (HR) for all-cause mortality in the lowest HGS quintile 1 (Q1) was 3.45 (2.14-5.58) for men and 3.3 (1.88-5.79) for women. For CVD mortality, the HR was 2.99 (1.07-8.37) for men and 10.35 (2.29-46.78) for women. The area under the curve (AUC) for HGS alone as a predictor of all-cause mortality was 0.791 (0.768-0.814) for men and 0.780 (0.752-0.807) for women (p < 0.05), while the AUC for HGS and age was 0.851 (0.830-0.871) for men and 0.848 (0.826-0.869) for women (p < 0.05). For CVD mortality, the AUC for HGS alone was 0.785 (95% CI 0.738-0.833) for men and 0.821 (95% CI 0.777-0.865) for women (p < 0.05), while the AUC for HGS and age as predictors of all-cause mortality was 0.853 (0.861-0.891) for men and 0.859 (0.821-0.896) for women (p < 0.05). The HGS Q1 (men <37.4 kg and women <24 kg) was matched separately for PSM. After univariate, multivariate Cox regression models, PSM, IPTW, SMRW, PA, and OW analyses, women had 2.37-3.12 and 2.92-5.12 HRs with low HGS for all-cause and CVD mortality, while men had 2.21-2.82 and 2.33-2.85 for all-cause and CVD mortality, respectively (p < 0.05).Conclusion: Adults with low HGS exhibited a significantly increased risk of both all-cause and CVD mortality, regardless of gender. Additionally, low HGS served as an independent risk factor and predictor for both all-cause and CVD mortality.

handgrip strength all-cause mortality CVD mortality NHANES propensity score-matched analysis

SCI

English

Corresponding

This research was supported by grants from the Science and Technology Planning Project of Shenzhen City, Guangdong Province, China (Nos. KCXFZ20201221173600001 and JCYJ20220818102605013).["KCXFZ20201221173600001","JCYJ20220818102605013"]

Nutrition & Dietetics

Nutrition & Dietetics

WOS:001075164900001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Geriatr, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Guangdong Prov Clin Res Ctr Geriatr, Shenzhen Clin Res Ctr Geriatr,Clin Med Coll 2,Jina, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Neurol, Shenzhen, Peoples R China
4.Jinan Univ, Postdoctoral Sci Res Stn Basic Med, Guangzhou, Peoples R China

Xiong, Lijiao,Zeng, Zhaohao,Wang, Shuojia,et al. The association of handgrip strength with all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination Survey database prospective cohort study with propensity score matching[J]. FRONTIERS IN NUTRITION,2023,10.

Xiong, Lijiao.,Zeng, Zhaohao.,Wang, Shuojia.,Liao, Tingfeng.,Wang, Xiaohao.,...&Liang, Zhen.(2023).The association of handgrip strength with all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination Survey database prospective cohort study with propensity score matching.FRONTIERS IN NUTRITION,10.

Xiong, Lijiao,et al."The association of handgrip strength with all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination Survey database prospective cohort study with propensity score matching".FRONTIERS IN NUTRITION 10(2023).