Supramolecular peptide nanotubes as artificial enzymes for catalysing ester hydrolysis

Song, Qiao1,2; Cheng, Zihe1; Perrier, Sebastien1,3,4

2023-09-01

10.1039/d3py00993

POLYMER CHEMISTRY   Impact Factor & Quartile

1759-9954

1759-9962

["Peptide-based artificial enzymes are attracting significant interest because of their remarkable resemblance in both composition and structure to native enzymes. Herein, we report the construction of histidine-containing cyclic peptide-based supramolecular polymeric nanotubes to function as artificial enzymes for ester hydrolysis. The optimized catalyst shows a ca. 70-fold increase in reaction rate compared to the un-catalysed reaction when using 4-nitrophenyl acetate as a model substrate. Furthermore, the amphiphilic nature of the supramolecular catalysts enables an enhanced catalytic activity towards hydrophobic substrates. By incorporating an internal hydrophobic region within the self-assembled polymeric nanotube, we achieve a 55.4-fold acceleration in hydrolysis rate towards a more hydrophobic substrate, 4-nitrophenyl butyrate. This study introduces supramolecular peptide nanotubes as an innovative class of supramolecular scaffolds for fabricating artificial enzymes with better structural and chemical stability, catalysing not only ester hydrolysis, but also a broader spectrum of catalytic reactions.","Histidine-containing cyclic peptide-based supramolecular peptide nanotubes were constructed to function as artificial enzymes for catalysing ester hydrolysis."]

SCI

English

Corresponding

The European Research Council (TUSUPO 647106; Q. S.; S. P.) is acknowledged for financial support. The authors thank the University of Warwick Polymer Characterization Research Technology Platform (RTP) for size exclusion chromatography facilities. We also[TUSUPO 647106]

Polymer Science

Polymer Science

WOS:001074571500001

ROYAL SOC CHEMISTRY

Web of Science

1.Univ Warwick, Dept Chem, Coventry CV4 7AL, England
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
3.Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England
4.Monash Univ, Fac Pharm & Pharmaceut Sci, Parkville, Vic 3052, Australia

Song, Qiao,Cheng, Zihe,Perrier, Sebastien. Supramolecular peptide nanotubes as artificial enzymes for catalysing ester hydrolysis[J]. POLYMER CHEMISTRY,2023.

Song, Qiao,Cheng, Zihe,&Perrier, Sebastien.(2023).Supramolecular peptide nanotubes as artificial enzymes for catalysing ester hydrolysis.POLYMER CHEMISTRY.

Song, Qiao,et al."Supramolecular peptide nanotubes as artificial enzymes for catalysing ester hydrolysis".POLYMER CHEMISTRY (2023).