南方科技大学知识苑(SUSTech KC): Photocatalytic <i>N</i>-Alkylation of <i>N</i>H-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes

Title	Photocatalytic N-Alkylation of NH-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes
Author	Wang, Cong1,2 ; Jia, Tiezheng2,3
Corresponding Author	Jia, Tiezheng
Publication Years	2023-09-01
DOI	10.1002/adsc.202300797
Source Title	ADVANCED SYNTHESIS & CATALYSIS Impact Factor & Quartile
ISSN	1615-4150
EISSN	1615-4169
Abstract	Sulfoximines, the isoelectronic with sulfones, represent a class of alternative and intriguing motifs in both discovery program and agrochemistry. N-Alkylation on imines could significantly improve their bioactivities, but the lack of general method has hindered their further uptake by medicinal chemistry and drug development. Herein, we present a mild photocatalytic anti-Markovnikov hydroamination of alkenes to construct N-alkylated sulfoximines with broad substrate tolerance on primary, secondary and tertiary alkyl substituents as well as a diverse range of sulfoximines. The mechanistic studies support the photocatalytic pathway, and demonstrate that the alkene radical cation rather than the iminium radical serves as the key intermediate in the transformation.
Keywords	Sulfoximines Alkylation Photocatalysis Hydroamination Alkenes
URL	[Source Record]
Indexed By	SCI
Language	English
SUSTech Authorship	Corresponding
Funding Project	This work is supported by Guangdong Basic and Applied Basic Research Foundation (2021B1515120046, 2022B1515120075, and 2022 A1515011770), and the Science and Technology Innovation Commission of Shenzhen Municipality (JCYJ20220818101404010, 2022081511321400["2021B1515120046","2022B1515120075","2022 A1515011770"] ; Guangdong Basic and Applied Basic Research Foundation["JCYJ20220818101404010","20220815113214003"]
WOS Research Area	Chemistry
WOS Subject	Chemistry, Applied ; Chemistry, Organic
WOS Accession No	WOS:001072141900001
Publisher	WILEY-V C H VERLAG GMBH
Data Source	Web of Science
Citation statistics	Cited Times [WOS]:0
Document Type	Journal Article
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/571885
Department	Department of Chemistry
Affiliation	1.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China 2.Southern Univ Sci & Technol, Res Ctr Chem Biol & Om Anal, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China 3.Nankai Univ, State Key Lab Elemento Organ Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China
First Author Affilication	Department of Chemistry
Corresponding Author Affilication	Department of Chemistry
Recommended Citation GB/T 7714	Wang, Cong,Jia, Tiezheng. Photocatalytic N-Alkylation of NH-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes[J]. ADVANCED SYNTHESIS & CATALYSIS,2023.
APA	Wang, Cong,&Jia, Tiezheng.(2023).Photocatalytic N-Alkylation of NH-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes.ADVANCED SYNTHESIS & CATALYSIS.
MLA	Wang, Cong,et al."Photocatalytic N-Alkylation of NH-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes".ADVANCED SYNTHESIS & CATALYSIS (2023).

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Photocatalytic N-Alkylation of NH-Sulfoximines via Anti-Markovnikov Hydroamination of Alkenes