| Title | Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis |
| Author | |
| Corresponding Author | Cha, Ruitao; Jiang, Xingyu |
| Publication Years | 2023-09-01
|
| DOI | |
| Source Title | |
| ISSN | 1936-0851
|
| EISSN | 1936-086X
|
| Abstract | Ulcerative colitis (UC) is a recurrent chronic inflammation of the colon with increasing incidence and prevalence, which could increase the risk of colorectal cancer. It is urgent to find an effective method with few side effects. Nanocrystalline cellulose (NCC), which is from plant fibers, has a good biocompatibility and high biosafety. Herein, we used NCC to treat UC and evaluated its treatment effect by the disease activity index, intestinal pathology, inflammatory cytokines, tight junction proteins, and mucins. We studied the impact of NCC on mucin expression and gut microbiota to discuss the therapeutic mechanism. NCC can effectively treat UC by regulating the MAPK pathway of mucin 2 and the relative abundance of Akkermansia and Odoribacter, which could not cause the body damage. NCC could not cause body damage compared to the medications, while it had a better effect on the regulation of MUC2 compared to the present drug substitutes. NCC is a practical alternative for the treatment of UC. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Key Ramp;amp;D Program of China["32171397","21875050","32071390","22234004"]
; National Natural Science Foundation of China[ZDSYS20200811144003009]
; Shenzhen Key Laboratory of Smart Healthcare Engineering[2022B1212010003]
; Guangdong Provincial Key Laboratory of Advanced Biomaterials["JCYJ20200109141231365","KQTD20190929172743294"]
; Shenzhen Science and Technology Program[2019ZT08Y191]
; Guangdong Innovative and Entrepreneurial Research Team Program[2019CX01Y196]
|
| WOS Research Area | Chemistry
; Science & Technology - Other Topics
; Materials Science
|
| WOS Subject | Chemistry, Multidisciplinary
; Chemistry, Physical
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
|
| WOS Accession No | WOS:001071969000001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/575808 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Lab Theoret & Computat Nanosci, Beijing 100190, Peoples R China 2.China Univ Geosci Beijing, Sch Mat Sci & Technol, Beijing Key Lab Mat Utilizat Nonmetall Minerals &, Natl Lab Mineral Mat, Beijing 100083, Peoples R China 3.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Guangdong, Peoples R China |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Wang, Mingzheng,Cha, Ruitao,Hao, Wenshuai,et al. Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis[J]. ACS NANO,2023.
|
| APA |
Wang, Mingzheng,Cha, Ruitao,Hao, Wenshuai,&Jiang, Xingyu.(2023).Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis.ACS NANO.
|
| MLA |
Wang, Mingzheng,et al."Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis".ACS NANO (2023).
|
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