中文版 | English
Title

N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry

Author
Corresponding AuthorShi, Zheng-Li
Publication Years
2023-09-29
DOI
Source Title
ISSN
0022-538X
EISSN
1098-5514
Abstract
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is highly pathogenic to piglets and poses a major threat to the swine industry. SADS-CoV has a wide cell tropism and pathogenic potential in younger animals. Therefore, understanding how SADS-CoV enters cells is essential for curbing its re-emergence and spread. Here, we report that tunicamycin, an N-linked glycoprotein inhibitor, inhibited the attachment of SADS-CoV to host cells, suggesting that the SADS-CoV receptor may be an N-linked glycoprotein but not Neu5Gc or Neu5Ac. Moreover, we found that exogenous trypsin, endogenous serine protease, cathepsin B, cathepsin L, and lysosomal acidification triggered SADS-CoV entry into cells. These findings improve our understanding of the molecular mechanisms underlying SADS-CoV entry and provide insights into the development of potential antiviral targets against SADS-CoV.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
WOS Research Area
Virology
WOS Subject
Virology
WOS Accession No
WOS:001075080100003
Publisher
ESI Research Field
MICROBIOLOGY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/575809
DepartmentDepartment of Chemistry
Affiliation
1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Southern Univ Sci & Technol, Coll Sci, Dept Chem, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Coll Sci, Res Ctr Chem Biol & Omics Anal, Shenzhen, Peoples R China
5.Guangzhou Lab, Guangzhou, Peoples R China
Recommended Citation
GB/T 7714
Chen, Ying,Liu, Xi,Zheng, Jiang-Nan,et al. N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry[J]. JOURNAL OF VIROLOGY,2023.
APA
Chen, Ying.,Liu, Xi.,Zheng, Jiang-Nan.,Yang, Li-Jun.,Luo, Yun.,...&Shi, Zheng-Li.(2023).N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry.JOURNAL OF VIROLOGY.
MLA
Chen, Ying,et al."N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry".JOURNAL OF VIROLOGY (2023).
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