Near-infrared laser-activated aggregation-induced emission nanoparticles boost tumor carbonyl stress and immunotherapy of breast cancer

Pan, You1; Suo, Meng2; Huang, Qinqin3; Lyu, Meng4,5; Jiang, Yi1; Wang, Shile3; Tang, Wenxue; Ning, Shipeng1,6; Zhang, Tianfu7

2023-10-01

10.1002/agt2.432

AGGREGATE   Impact Factor & Quartile

2692-4560

["The induction of tumor carbonyl stress is reported to efficiently revert immune suppression in the tumor microenvironment and enhance cancer immunotherapy. However, low oxygen concentration due to inherent tumor hypoxia limits its catalytic effect. Herein, an injectable thermosensitive hydrogel system (named APH) is developed for co-loading of near-infrared (NIR) aggregation-induced emission (AIE) nanoparticles and plasma amine oxidase (PAO) for boosting carbonyl stress and enhancing antitumor immunity. Upon 808 nm NIR laser irradiation, the AIE nanoparticles trigger a mild-temperature (around 45 & DEG;C) photothermal effect in the tumor site, which significantly relieves tumor hypoxia and promotes the catalytic effect of released PAO to inhibit the growth of Myeloid-derived suppressor cells. Remarkably, the synergistic therapeutic effect of APH is verified through a significant inhibitory effect on the distant tumor, enhanced immune memory, and effective suppression of postoperative recurrence, rechallenge, and metastasis. Overall, the combined effect of AIE-mediated photothermal therapy and carbonyl stress by APH upon NIR irradiation therapy can significantly activate cancer immunotherapy, making it a promising treatment approach for cancer treatment.","A synergistic strategy of combining mild photothermal therapy and carbonyl stress is accomplished by an AIE-based hydrogel system, which relieves tumor hypoxia and activated anti-tumor immunity. Remarkably, the induced cancer immunotherapy significantly inhibits distant tumor growth, enhances immune memory and suppresses postoperative recurrence, rechallenge and metastasis, making it a promising cancer treatment approach.image"]

aggregation-induced emission cancer recurrence immunotherapy photothermal therapy tumor carbonyl stress

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We are grateful for the financial support from the National Natural Science Foundation of China (82002779), the Guangxi Natural Science Foundation under Grant No. 2023GXNSFBA026137, and the China Postdoctoral Science Foundation (2022M710853). Thanks to the[82002779] ; National Natural Science Foundation of China[2023GXNSFBA026137] ; Guangxi Natural Science Foundation[2022M710853]

Chemistry ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary

WOS:001073994600001

WILEY

Web of Science

1.Guangxi Med Univ, Dept Breast Surg, Affiliated Hosp 2, Nanning, Peoples R China
2.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou, Peoples R China
3.Zhengzhou Univ, Acad Med Sci, Precis Med Ctr, Zhengzhou, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Gastrointes, Shenzhen, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Clin Med Coll 2,Dept Geriatr,Shenzhen Peoples Hosp, Shenzhen, Peoples R China
6.TheSecond Affiliated Hosp Guangxi Med Univ, Dept Breast Surg, Nanning 530000, Peoples R China
7.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou 511436, Peoples R China

Pan, You,Suo, Meng,Huang, Qinqin,et al. Near-infrared laser-activated aggregation-induced emission nanoparticles boost tumor carbonyl stress and immunotherapy of breast cancer[J]. AGGREGATE,2023.

Pan, You.,Suo, Meng.,Huang, Qinqin.,Lyu, Meng.,Jiang, Yi.,...&Zhang, Tianfu.(2023).Near-infrared laser-activated aggregation-induced emission nanoparticles boost tumor carbonyl stress and immunotherapy of breast cancer.AGGREGATE.

Pan, You,et al."Near-infrared laser-activated aggregation-induced emission nanoparticles boost tumor carbonyl stress and immunotherapy of breast cancer".AGGREGATE (2023).