| Title | Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of a-dehydro amino ketones |
| Author | |
| Corresponding Author | Tan, Xuefeng; Ding, Xiaobing; Chen, Gen-Qiang; Zhang, Xumu |
| Publication Years | 2023-09-01
|
| DOI | |
| Source Title | |
| ISSN | 1674-7291
|
| EISSN | 1869-1870
|
| Abstract | A series of novel atropisomeric diphosphine ligands termed TanPhos were designed and synthesized, which has a smaller bite angle compared with that of other ligands such as BINAP. TanPhos showed high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of a-dehydro amino ketones, and up 99% yield and 99% ee were obtained for a wide range of chiral & alpha;-amino ketones. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Key R&D Program of China[2021YFA1500201]
; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002]
; Key-Area Research and Development Program of Guangdong Province[2020B010188001]
; Innovative Team of Universities in Guangdong Province[2020KCXTD016]
; National Natural Science Foundation of China["21991113","22171129"]
; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055]
; Shenzhen Science and Technology Innovation Committee[JCYJ20210324104202007]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:001068479600001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/575829 |
| Department | Department of Chemistry 前沿与交叉科学研究院 |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Chem, Lab Small Mol Drug Discovery & Synth, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518000, Peoples R China 3.City Univ Hong Kong, Dept Chem, Hong Kong 999077, Peoples R China |
| First Author Affilication | Department of Chemistry |
| Corresponding Author Affilication | Department of Chemistry; Academy for Advanced Interdisciplinary Studies |
| First Author's First Affilication | Department of Chemistry; Academy for Advanced Interdisciplinary Studies |
| Recommended Citation GB/T 7714 |
Tan, Xuefeng,Gao, Shuang,Yang, Chunyan,et al. Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of a-dehydro amino ketones[J]. SCIENCE CHINA-CHEMISTRY,2023.
|
| APA |
Tan, Xuefeng.,Gao, Shuang.,Yang, Chunyan.,Lang, Qiwei.,Ding, Xiaobing.,...&Zhang, Xumu.(2023).Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of a-dehydro amino ketones.SCIENCE CHINA-CHEMISTRY.
|
| MLA |
Tan, Xuefeng,et al."Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of a-dehydro amino ketones".SCIENCE CHINA-CHEMISTRY (2023).
|
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