Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives

Yue, Ning-ning1; Xu, Hao-ming2; Xu, Jing2; Zhu, Min-zheng3; Zhang, Yuan4; Tian, Cheng-Mei5; Nie, Yu-qiang2; Yao, Jun6; Liang, Yu-jie7; Li, De-feng6; Wang, Li-sheng6

2023-09-21

10.1016/j.omto.2023.08.007

MOLECULAR THERAPY-ONCOLYTICS   Impact Factor & Quartile

2372-7705

Advancements in understanding the pathogenesis mechanisms underlying gastrointestinal diseases, encompassing inflamma-tory bowel disease, gastrointestinal cancer, and gastroesophageal reflux disease, have led to the identification of numerous novel therapeutic targets. These discoveries have opened up exciting possibilities for developing gene therapy strategies to treat gastrointestinal diseases. These strategies include gene replacement, gene enhancement, gene overexpression, gene function blocking, and transgenic somatic cell transplantation. In this review, we introduce the important gene therapy targets and targeted delivery systems within the field of gastroenterology. Furthermore, we provide a comprehensive overview of recent progress in gene therapy related to gastrointestinal disorders and shed light on the application of innovative gene-editing technologies in treating these conditions. These developments are fueling a revolution in the management of gastrointestinal diseases. Ultimately, we discuss the current challenges (particularly regarding safety, oral efficacy, and cost) and explore potential future directions for implementing gene therapy in the clinical settings for gastrointestinal diseases.

SCI

English

Corresponding

Science and Technology Innovation Committee of Shenzhen["JCYJ20150403101028164","JCYC20170 307100911479","JCYJ20190807145617113","JCYJ20210324113802006","JCYJ20220530151810024"]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:001068289500001

CELL PRESS

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen 518000, Peoples R China
2.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou 510000, Peoples R China
3.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou 518000, Peoples R China
4.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou 516000, Guangdong, Peoples R China
5.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Emergency,Clin Med Coll 2, Shenzhen 518000, Peoples R China
6.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Gastroenterol,Clin Med Coll, Shenzhen 518000, Peoples R China
7.Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, Shenzhen 518000, Peoples R China

Yue, Ning-ning,Xu, Hao-ming,Xu, Jing,et al. Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives[J]. MOLECULAR THERAPY-ONCOLYTICS,2023,30.

Yue, Ning-ning.,Xu, Hao-ming.,Xu, Jing.,Zhu, Min-zheng.,Zhang, Yuan.,...&Wang, Li-sheng.(2023).Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives.MOLECULAR THERAPY-ONCOLYTICS,30.

Yue, Ning-ning,et al."Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives".MOLECULAR THERAPY-ONCOLYTICS 30(2023).