A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV
Cong,Sun1; Yin-Feng,Kang1; Xin-Yan,Fang2; Yi-Na,Liu1; Guo-Long,Bu1; Ao-Jie,Wang2; Yan,Li1; Qian-Ying,Zhu1; Hua,Zhang1,3; Chu,Xie1; Xiang-Wei,Kong1; Yong-Jian,Peng1; Wen-Jie,Lin1; Ling,Zhou1; Xin-Chun,Chen1; Zheng-Zhou,Lu1; Hui-Qin,Xu2; Dong-Chun,Hong1; Xiao,Zhang1; Ling,Zhong1; Guo-Kai,Feng1; Yi-Xin,Zeng1; Miao,Xu1; Qian,Zhong1; Zheng,Liu2; Mu-Sheng,Zeng1
|Corresponding Author||Qian,Zhong; Zheng,Liu; Mu-Sheng,Zeng|
|Joint first author||Cong,Sun; Yin-Feng,Kang; Xin-Yan,Fang; Yi-Na,Liu|
Epstein-Barr virus (EBV) is a global public health concern, as it is known to cause multiple diseases while also being etiologically associated with a wide range of epithelial and lymphoid malignancies. Currently, there is no available prophylactic vaccine against EBV. gB is the EBV fusion protein that mediates viral membrane fusion and participates in host recognition, making it critical for EBV infection in both B cells and epithelial cells. Here, we present a gB nanoparticle, gB-I53-50 NP, that displays multiple copies of gB. Compared with the gB trimer, gB-I53-50 NP shows improved structural integrity and stability, as well as enhanced immunogenicity in mice and non-human primate (NHP) preclinical models. Immunization and passive transfer demonstrate a robust and durable protective antibody response that protects humanized mice against lethal EBV challenge. This vaccine candidate demonstrates significant potential in preventing EBV infection, providing a possible platform for developing prophylactic vaccines for EBV.
NI Journal Papers
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Cryo-Electron Microscopy Center|
1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China
2.Cryo-Electron Microscopy Center, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China
3.MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, China
|Corresponding Author Affilication||Cryo-Electron Microscopy Center|
Cong,Sun,Yin-Feng,Kang,Xin-Yan,Fang,et al. A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV[J]. Cell Host & Microbe,2023,31(11):1882-1897.
Cong,Sun.,Yin-Feng,Kang.,Xin-Yan,Fang.,Yi-Na,Liu.,Guo-Long,Bu.,...&Mu-Sheng,Zeng.(2023).A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV.Cell Host & Microbe,31(11),1882-1897.
Cong,Sun,et al."A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV".Cell Host & Microbe 31.11(2023):1882-1897.
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