The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Xu, Long1,2; Yan, Xiaoyu1; Wang, Jian1; Zhao, Yuanxin1; Liu, Qingqing1; Fu, Jiaying1; Shi, Xinyi1; Su, Jing1

2023-10-01

10.3390/ijms242015066

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Impact Factor & Quartile

1661-6596

1422-0067

Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylases (HDACs) are enzymes that can catalyze the deacetylation of histone and some non-histone proteins and that are involved in the regulation of a variety of biological processes via the regulation of gene transcription and the functions of non-histone proteins such as transcription factors and enzymes. Aberrant expressions of HDACs are common in ovarian cancer. Many studies have found that HDACs are involved in regulating a variety of events associated with ovarian cancer metastasis, including cell migration, invasion, and the epithelial-mesenchymal transformation. Herein, we provide a brief overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. In addition, we discuss the roles of HDACs in the regulation of ovarian cancer metastasis. Finally, we discuss the development of compounds that target HDACs and highlight their importance in the future of ovarian cancer therapy.

ovarian cancer metastasis histone deacetylases histone deacetylase inhibitors

SCI

English

Others

Jilin Province science and technology development plan project[20230505046ZP] ; Jilin Province health science and technology ability improvement project["2021JC034","2022JC045"] ; Norman Bethune Project Plan of Jilin University[2023B32]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:001089850500001

MDPI

CHEMISTRY

Web of Science

1.Jilin Univ, Coll Basic Med Sci, Dept Pathophysiol, Key Lab Pathobiol,Minist Educ, 126 Xinmin St, Changchun 130021, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518000, Peoples R China

Xu, Long,Yan, Xiaoyu,Wang, Jian,et al. The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(20).

Xu, Long.,Yan, Xiaoyu.,Wang, Jian.,Zhao, Yuanxin.,Liu, Qingqing.,...&Su, Jing.(2023).The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(20).

Xu, Long,et al."The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.20(2023).