| Title | Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch |
| Author | |
| Corresponding Author | Luo, Zhi; Leroux, Jean-Christophe |
| Publication Years | 2023-09-27
|
| DOI | |
| Source Title | |
| ISSN | 1946-6234
|
| EISSN | 1946-6242
|
| Volume | 15Issue:715 |
| Abstract | Biopharmaceuticals, including proteins and peptides, have revolutionized the treatment of a wide range of diseases, from diabetes and cardiovascular disorders to virus infections and cancer. Despite their efficacy, most of these macromolecular drugs require parenteral administration because of their high molecular weight and relative instability. Over the past 40 years, only a few oral peptide drugs have entered clinical trials, even when formulated with substantial amounts of permeation enhancers. To overcome the epithelial barrier, devices that inject drugs directly into the gastrointestinal mucosa have been proposed recently. However, the robustness and safety of those complex systems are yet to be assessed. In this study, we introduced an innovative technology to boost drug absorption by synergistically combining noninvasive stretching of the buccal mucosa with permeation enhancers. Inspired by the unique structural features of octopus suckers, a self-applicable suction patch was engineered, enabling strong adhesion to and effective mechanical deformation of the mucosal tissue. In dogs, this suction patch achieved bioavailability up to two orders of magnitude higher than those of the commercial tablet formulation of desmopressin, a peptide drug known for its poor oral absorption. Moreover, systemic exposure comparable to that of the approved oral semaglutide tablet was achieved without further optimization. Last, a first-in-human study involving 40 healthy participants confirmed the dosage form's acceptability, thereby supporting the clinical translatability of this simple yet effective platform technology. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Key Research and Development Program of China[2022YFB3804700]
; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]
; ETH Zurich Research Grants[33 20-1]
|
| WOS Research Area | Cell Biology
; Research & Experimental Medicine
|
| WOS Subject | Cell Biology
; Medicine, Research & Experimental
|
| WOS Accession No | WOS:001082818900002
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/582873 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China 2.ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Luo, Zhi,Klein Cerrejon, David,Romer, Simon,et al. Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch[J]. SCIENCE TRANSLATIONAL MEDICINE,2023,15(715).
|
| APA |
Luo, Zhi,Klein Cerrejon, David,Romer, Simon,Zoratto, Nicole,&Leroux, Jean-Christophe.(2023).Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch.SCIENCE TRANSLATIONAL MEDICINE,15(715).
|
| MLA |
Luo, Zhi,et al."Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch".SCIENCE TRANSLATIONAL MEDICINE 15.715(2023).
|
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