Toxic vascular effects of polystyrene microplastic exposure

Yan, Jianlong1,2; Pan, Yanbin2,3; He, Junbo1,2; Pang, Xinli1,2; Shao, Wenming4; Wang, Caiping1,2; Wang, Rongning1,2; He, Yaqiong1,2; Zhang, Min1,2; Ye, Juheng1,2; Lin, Chaolan1,2; Lin, Feng1,2; Wang, Yongshun1,2; Li, Tangzhiming1,2; Lan, Yu1,2; Guo, Yanbin1,2; Wang, Minxian5; Sun, Mengting5; Gong, Yun1,2; Yuan, Mingpei1,2; Sun, Xin1,2; Dong, Shaohong1,2

2023-12-20

10.1016/j.scitotenv.2023.167215

SCIENCE OF THE TOTAL ENVIRONMENT   Impact Factor & Quartile

0048-9697

1879-1026

Polystyrene microplastics (PSMPs) are some of the most common microplastic components, and the resulting pollution has become a global problem. Extensive studies have been conducted on the toxic effects of PSMPs on the heart, lungs, liver, kidneys, nerves, intestines and other tissues. However, the impact of PSMPs on vascular toxicity is poorly understood at present. The aim of this study was to reveal the vascular toxicity of microplastics (MPs). Patients were assigned to a calcification group (25 patients) or a non-calcification group (22 patients) based on the presence or absence of calcification in the thoracic aorta wall. We detected 7 polymer types in human feces. Patients with vascular calcification (VC) had higher levels of total MPs, polypropylene (PP) and polystyrene (PS) in feces than patients without VC. The thoracic aortic calcification score was significantly positively correlated with the total MP abundance (Spearman r = 0.8109, p < 0.0001), PP (Spearman r = 0.7211, p = 0.0160) and PS (Spearman r = 0.6523, p = 0.0471) in feces. We then explored the effects of PSMP exposure on normal and vitamin D3 + nicotine (VDN)-treated rats. PSMP exposure induced mild VC in normal rats and aggravated VC in VDN-treated rats. PSMP exposure disturbed the gut microbiota, causing Proteobacteria and Escherichia_Shigella to be the dominant phylum and genus, respectively. It also induced intestinal inflammatory responses in normal rats, aggravated intestinal inflammation in VDN-treated rats, impaired the intestinal mucosal barrier, and increased intestinal permeability. This study provides a theoretical basis for the risk assessment of MP-induced cardiovascular disease.

Microplastics Vascular calcification Intestinal microbiota Toxicity Inflammation

SCI

English

Corresponding

Clinical Research and Cultivation Project of Shenzhen People's Hospital[SYLCYJ202110] ; Middle-aged and Young Research Talent Cultivation Project of Shenzhen People's Hospital[SYJCY202101] ; Guangdong Medical Scientific Research[A2021418] ; Shenzhen Science and Technology Innovation Committee (SZSTI)[RCYX20221008092950121] ; National Natural Science Foundation of China["81770496","82000058","82070517"] ; Shenzhen Key Medical Discipline Construction Fund[SZXK003] ; Sanming Project of Medicine in Shenzhen[SZSM201412012] ; Science and Technology Planning Project of Shenzhen Municipality[JCYJ20170307100512856] ; Shenzhen Science and Technology Program[JCYJ20220530151804009]

Environmental Sciences & Ecology

Environmental Sciences

WOS:001085006500001

ELSEVIER

ENVIRONMENT/ECOLOGY

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Cardiovasc Minimally Invas Med Engn Techn, Dept Cardiol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Hlth Management Ctr, Shenzhen 518020, Guangdong, Peoples R China
4.Jinan Univ, Dept Emergency, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China
5.Dalian Med Univ, Dalian 116000, Liaoning, Peoples R China

Yan, Jianlong,Pan, Yanbin,He, Junbo,et al. Toxic vascular effects of polystyrene microplastic exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,905.

Yan, Jianlong.,Pan, Yanbin.,He, Junbo.,Pang, Xinli.,Shao, Wenming.,...&Dong, Shaohong.(2023).Toxic vascular effects of polystyrene microplastic exposure.SCIENCE OF THE TOTAL ENVIRONMENT,905.

Yan, Jianlong,et al."Toxic vascular effects of polystyrene microplastic exposure".SCIENCE OF THE TOTAL ENVIRONMENT 905(2023).