Prognostic Value of Inflammation Biomarkers in Penile Squamous Cell Carcinoma Patients Without Distant Metastasis

Xue, Ting1,2,3; Li, Zai-Shang4,5,6; Wu, Chong7; Li, Yong-Hong1,2,3; Liu, Zhuo-Wei1,2,3; Qin, Zi-Ke1,2,3; Yao, Kai1,2,3; Zhou, Fang-Jian1,2,3; Han, Hui1,2,3

2023-10-01

10.1016/j.clgc.2023.03.014

CLINICAL GENITOURINARY CANCER   Impact Factor & Quartile

1558-7673

1938-0682

A total of 271 penile squamous cell carcinoma patients (PSCC) without distant metastasis were enrolled in this study. Inflammatory biomarkers were associated with the prognostic of PSCC patients. A nomogram based on inflammation biomarkers to predict the overall survival of PSCC patients was constructed with superior predictive ability and high clinical use. The nomogram based on the inflammation biomarkers may serve as a tool in predicting the survival of PSCC patients.Background: To investigate the value of the presurgical inflammatory biomarkers including C-reactive protein (CRP), albumin (ALB), C-reactive protein to albumin ratio (CAR), Glasgow prognostic score (GPS), the modified GPS (mGPS), and the high-sensitivity modified GPS (Hs-mGPS) in penile squamous cell carcinoma (PSCC) without distant metastasis and develop a tool to predict the overall survival (OS) of PSCC patients. Methods: We retrospectively enrolled 271 PSCC patients without distant metastasis from 2006 to 2021. Patients were divided into 2 cohorts by a 7:3 ratio-a training cohort (n = 191) and a validation cohort (n = 80). We performed cox regression analyses on the training cohort and constructed a nomogram to predict OS over 1, 3, and 5 years. Data from the validation cohort was used to validate the nomogram's predictive power. Results: According to Kaplan-Meier analysis, elevated CRP ( P < .001), hypoalbuminemia ( P = .008), higher CAR ( P < .001), higher GPS score ( P < .001), higher mGPS score ( P < .001), and higher Hs-mGPS score ( P = .015) were associated with a decreased overall survival. GPS score, along with age, pathology N stage, and grade, was found to be an independent risk factor for poor prognosis in the multivariate analysis. We constructed a nomogram based on the prespecified variables predicting 1-, 3-and 5-year OS. The C-indexes of the nomogram in the training and validation cohorts were 0.871 and 0.869, respectively. The decision curve analysis showed that the nomogram had a larger net benefit. The Kaplan-Meier curves showed significant differences between the risk groups categorized according to the nomogram ( P < .001). Conclusions: Inflammation biomarkers of systemic inflammation and nutritional status play an important role in individual OS predictions for PSCC patients without distant monitoring. The establishment of the nomogram provided a tool to predict the survival of 1-, 3-, and 5-year OS in PSCC patients without distant metastasis.

Survival CRP Albumin GPS score

SCI

English

Others

Natural Science Foundation of Guangdong Province, China[2022A1515012321] ; Guangdong Province Nature Foundation of China Project[2022A1515012200] ; Science and Technology Planning Project of Shenzhen Municipality[JCYJ20190807145409328] ; Shenzhen Science and Technology Program[RCYX20221008093032008]

Oncology ; Urology & Nephrology

Oncology ; Urology & Nephrology

WOS:001085347900001

CIG MEDIA GROUP, LP

Web of Science

1.Sun Yat Sen Univ, Canc Ctr, Dept Urol, Guangzhou, Peoples R China
2.Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Peoples R China
3.Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China
4.Jinan Univ, Second Clin Coll, Shenzhen Peoples Hosp, Dept Cardiol, Shenzhen, Peoples R China
5.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Urol, Shenzhen, Peoples R China
6.Shenzhen Res & Dev Ctr Med Engn & Technol, Minimally Invas Urol, Shenzhen, Peoples R China
7.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou, Guangdong, Peoples R China

Xue, Ting,Li, Zai-Shang,Wu, Chong,et al. Prognostic Value of Inflammation Biomarkers in Penile Squamous Cell Carcinoma Patients Without Distant Metastasis[J]. CLINICAL GENITOURINARY CANCER,2023,21(5).

Xue, Ting.,Li, Zai-Shang.,Wu, Chong.,Li, Yong-Hong.,Liu, Zhuo-Wei.,...&Han, Hui.(2023).Prognostic Value of Inflammation Biomarkers in Penile Squamous Cell Carcinoma Patients Without Distant Metastasis.CLINICAL GENITOURINARY CANCER,21(5).

Xue, Ting,et al."Prognostic Value of Inflammation Biomarkers in Penile Squamous Cell Carcinoma Patients Without Distant Metastasis".CLINICAL GENITOURINARY CANCER 21.5(2023).