| Title | NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers |
| Author | |
| Corresponding Author | Zhang, Wenyong |
| Publication Years | 2023-10-01
|
| DOI | |
| Source Title | |
| ISSN | 1661-6596
|
| EISSN | 1422-0067
|
| Volume | 24Issue:19 |
| Abstract | Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation[pdjh202023c21804]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Chemistry
|
| WOS Subject | Biochemistry & Molecular Biology
; Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:001082973800001
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/582917 |
| Department | School of Medicine |
| Affiliation | 1.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Key Univ Lab Metab & Hlth Guangdong, Shenzhen 518055, Peoples R China |
| First Author Affilication | School of Medicine |
| Corresponding Author Affilication | School of Medicine; Southern University of Science and Technology |
| First Author's First Affilication | School of Medicine |
| Recommended Citation GB/T 7714 |
Zhou, Yujie,Yu, Songyan,Zhang, Wenyong. NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(19).
|
| APA |
Zhou, Yujie,Yu, Songyan,&Zhang, Wenyong.(2023).NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(19).
|
| MLA |
Zhou, Yujie,et al."NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.19(2023).
|
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