Phenylboronic Acid-Modified Gold Nanoclusters as a Nanoantibiotic to Treat Vancomycin-Resistant Enterococcus faecalis-Caused Infections

Wang, Le1,2; Zheng, Wenfu3; Zhong, Leni1; Yang, Yingkun1,4; Chen, Yao1; Hou, Qinghong1; Yu, Peiyuan1; Jiang, Xingyu1

2023-10-10

10.1021/acsnano.3c02886

ACS NANO   Impact Factor & Quartile

1936-0851

1936-086X

Vancomycin is one of the last lines of defense against certain drug-resistant bacteria-caused infections. However, the high susceptibility to drug resistance and high toxicity seriously limit the application of vancomycin. Nanoantibiotics provide opportunities to solve these problems. Herein, we present mercaptophenylboronic acid (MBA)-modified gold nanoclusters with well-defined molecular formulas and structure (Au-44(MBA)(18)) and excellent antibacterial activities against various drug-resistant bacteria such as vancomycin-resistant Enterococcus faecalis (VRE). Au-44(MBA)(18) interacts with bacteria by first attaching to teichoic-acid and destroying the cell wall and subsequently binding to the bacterial DNA. Au-44(MBA)(18) could be administered via multiple routes and has a high biosafety (500 mg/kg, no ototoxicity), overcoming the two major shortcomings of vancomycin (sole administration route and high ototoxicity). Our study is insightful for curing infections caused by multidrug-resistant bacteria using nanoantibiotics with high biosafety.

antibacterial gold nanoclusters nanoantibiotics vancomycin-resistant bacteria ototoxicity multiple administration modes

SCI

English

NI Journal Papers

First ; Corresponding

National Key R&D Program of China["2020YFA0908900","2018YFA0902600","2021YFF1200100","2021YFF1200800","2022YFB3804700"] ; National Natural Science Foundation of China["22234004","22304065","81730051","32071390"] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141231365"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Guangdong Major Talent Introduction Project[2019CX01Y196] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001082611400001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China
2.Jiangxi Univ Chinese Med, Canc Res Ctr, Nanchang 330004, Jiangxi, Peoples R China
3.GBA Res Innovat Inst Nanotechnol, Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
4.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong 999077, Peoples R China

Wang, Le,Zheng, Wenfu,Zhong, Leni,et al. Phenylboronic Acid-Modified Gold Nanoclusters as a Nanoantibiotic to Treat Vancomycin-Resistant Enterococcus faecalis-Caused Infections[J]. ACS NANO,2023,17(20).

Wang, Le.,Zheng, Wenfu.,Zhong, Leni.,Yang, Yingkun.,Chen, Yao.,...&Jiang, Xingyu.(2023).Phenylboronic Acid-Modified Gold Nanoclusters as a Nanoantibiotic to Treat Vancomycin-Resistant Enterococcus faecalis-Caused Infections.ACS NANO,17(20).

Wang, Le,et al."Phenylboronic Acid-Modified Gold Nanoclusters as a Nanoantibiotic to Treat Vancomycin-Resistant Enterococcus faecalis-Caused Infections".ACS NANO 17.20(2023).