中文版 | English
Title

Immune checkpoint inhibitors-related pancreatitis with fulminant type 1 diabetes mellitus: case report and literature review

Author
Corresponding AuthorGao, Yang; Wang, Huanping
Publication Years
2023-09-28
DOI
Source Title
ISSN
1664-3224
Volume14
Abstract
Immune checkpoint inhibitors (ICIs) are increasingly being used in the treatment of advanced human malignancies. ICIs-related adverse events, including pancreatitis and diabetes, have been individually characterized in the literature. The co-occurrence of ICIs-related pancreatitis with diabetes is rare and easily overlooked, but it is often severe or fatal. We present a patient with renal tumor resection who was treated with injection of the PD-L1 inhibitor toripalimab and eventually developed acute pancreatitis and fulminant type 1 diabetes mellitus. In addition, we conducted a literature review of ICIs-related pancreatitis with diabetes. The case in our report presented with paroxysmal abdominal pain and loss of appetite. Intravenous fluids and insulin infusion improved the patient's pancreatitis and explosive hyperglycemia. This article suggests that ICIs can affect endocrine and exocrine functions of the pancreas, while providing information and new perspectives for the diagnosis and treatment of this challenging rare disease, helping inspire clinicians for the early identification and effective management of similar cases.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Youth Science and Technology Innovation Project of the Department of Science and Technology of Sichuan Province["2021049","2022082"] ; Sichuan Traditional Chinese Medicine Culture Collaborative Development Research Center Project[2022XT101]
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:001081210100001
Publisher
Data Source
Web of Science
Citation statistics
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/582937
DepartmentSchool of Medicine
Affiliation
1.Chengdu Shuangliu Hosp Tradit Chinese Med, Dept Anorectal, Chengdu 610200, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Ultrasound, Chengdu, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Dept Human Cell Biol & Genet, Shenzhen, Peoples R China
4.Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China
Recommended Citation
GB/T 7714
Fang, Wei,Gao, Yang,Shi, Xiaoyan,et al. Immune checkpoint inhibitors-related pancreatitis with fulminant type 1 diabetes mellitus: case report and literature review[J]. FRONTIERS IN IMMUNOLOGY,2023,14.
APA
Fang, Wei.,Gao, Yang.,Shi, Xiaoyan.,Zhang, Xiaoran.,Zhou, Shan.,...&Wang, Huanping.(2023).Immune checkpoint inhibitors-related pancreatitis with fulminant type 1 diabetes mellitus: case report and literature review.FRONTIERS IN IMMUNOLOGY,14.
MLA
Fang, Wei,et al."Immune checkpoint inhibitors-related pancreatitis with fulminant type 1 diabetes mellitus: case report and literature review".FRONTIERS IN IMMUNOLOGY 14(2023).
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