| Title | Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration |
| Author | |
| Corresponding Author | Bai, Jiaming; Wang, Min |
| Publication Years | 2023-10-25
|
| DOI | |
| Source Title | |
| ISSN | 2050-750X
|
| EISSN | 2050-7518
|
| Volume | 11Issue:41 |
| Abstract | Scaffolds are an essential component in bone tissue engineering (BTE). However, most of the current BTE scaffolds are homogeneous structures and do not resemble the graded architectures of native bone. In the current study, four types of biomimicking scaffold designs based on gyroid (G) and primitive (P) units with radially graded pore sizes were devised, and scaffolds of these designs with two porosity groups (65 vol% and 75 vol%) were fabricated via digital light processing (DLP) 3D printing using biphasic calcium phosphate (BCP). Scaffolds of the gyroid-gyroid (G-G) design displayed better dimensional accuracy, compressive property, and cell proliferation rate than gyroid-primitive (G-P), primitive-gyroid (P-G), and primitive-primitive (P-P) scaffolds. Subsequently, graded G-G scaffolds with different porosities were fabricated and the relationship between compressive strength and porosity was determined. Furthermore, the sintered BCP bioceramics fabricated via current manufacturing process exhibited excellent biocompatibility and bioactivity, indicating their high potential for BTE. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Southern University of Science and Technology (SUSTech)[2022YFE0197100]
; National Key Ramp;D Program of China["GJHZ20200731095606021","KQTD20190929172505711"]
; Shenzhen Science and Technology Innovation Commission["17200519","17202921","17201622","N_HKU749/22"]
|
| WOS Research Area | Materials Science
|
| WOS Subject | Materials Science, Biomaterials
|
| WOS Accession No | WOS:001082329300001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/582943 |
| Department | Department of Mechanical and Energy Engineering |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China 2.Univ Hong Kong, Dept Mech Engn, Pokfulam Rd, Hong Kong, Peoples R China |
| First Author Affilication | Department of Mechanical and Energy Engineering |
| Corresponding Author Affilication | Department of Mechanical and Energy Engineering |
| First Author's First Affilication | Department of Mechanical and Energy Engineering |
| Recommended Citation GB/T 7714 |
Wang, Yue,Chen, Shangsi,Liang, Haowen,et al. Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration[J]. JOURNAL OF MATERIALS CHEMISTRY B,2023,11(41).
|
| APA |
Wang, Yue,Chen, Shangsi,Liang, Haowen,Bai, Jiaming,&Wang, Min.(2023).Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration.JOURNAL OF MATERIALS CHEMISTRY B,11(41).
|
| MLA |
Wang, Yue,et al."Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration".JOURNAL OF MATERIALS CHEMISTRY B 11.41(2023).
|
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