中文版 | English
Title

c-Jun as a one-way valve at the naive to primed interface

Author
Corresponding AuthorLi, Dongwei; Pei, Duanqing
Publication Years
2023-10-14
DOI
Source Title
EISSN
2045-3701
Volume13Issue:1
Abstract
Backgroundc-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells. However, its role in early embryonic development remains unknown.ResultsHere, we show that c-Jun acts as a one-way valve to preserve the primed state and impair reversion to the naive state. c-Jun is induced during the naive to primed transition, and it works to stabilize the chromatin structure and inhibit the reverse transition. Loss of c-Jun has surprisingly little effect on the naive to primed transition, and no phenotypic effect on primed cells, however, in primed cells the loss of c-Jun leads to a failure to correctly close naive-specific enhancers. When the primed cells are induced to reprogram to a naive state, these enhancers are more rapidly activated when c-Jun is lost or impaired, and the conversion is more efficient.ConclusionsThe results of this study indicate that c-Jun can function as a chromatin stabilizer in primed EpiSCs, to maintain the epigenetic cell type state and act as a one-way valve for cell fate conversions.
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URL[Source Record]
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Language
English
SUSTech Authorship
Others
Funding Project
This work was supported in part by the National Natural Science Foundation of China (32270574, 31830060, 92068201, 81570279, 81974019, 32150710521), Major State Basic Research Development Program (2017YFA0504100), National Key Research and Development Prog["32270574","31830060","92068201","81570279","81974019","32150710521"] ; National Natural Science Foundation of China[2017YFA0504100] ; Major State Basic Research Development Program["2018YFA0108700","2017YFA0105602"] ; National Key Research and Development Program of China[81720108004] ; NSFC Projects of International Cooperation and Exchanges["2019348","2023A03J0045"] ; Youth Innovation Promotion of the Chinese Academy of Sciences[2020XXG002] ; Guangdong Cardiovascular Institute["DFJHBF202110","DFJHBF202111"]
WOS Research Area
Biochemistry & Molecular Biology
WOS Subject
Biochemistry & Molecular Biology
WOS Accession No
WOS:001084294900001
Publisher
Data Source
Web of Science
Citation statistics
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/582951
DepartmentSchool of Life Sciences
生命科学学院_系统生物学系
Affiliation
1.Guangzhou Med Univ, Therapy & Rehabil Guangdong Higher Educ Inst, Key Lab Biol Targeting Diag, Affiliated Hosp 5, 190 Kaiyuan Dadao, Guangzhou 510799, Peoples R China
2.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci,Dept Guangdong Prov Key Lab, Guangzhou 510100, Guangdong, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Ctr Cell Lineage & Dev, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Peoples R China
4.Guangzhou Regenerat Med & Hlth Guangdong Lab, Bioland Lab, Guangzhou 510005, Peoples R China
5.Southern Univ Sci & Technol, Sch Life Sci, Dept Syst Biol, Shenzhen 518055, Peoples R China
6.Westlake Univ, Sch Life Sci, Lab Cell Fate Control, 18 Longshan St, Hangzhou 310024, Peoples R China
Recommended Citation
GB/T 7714
Li, Dongwei,Luo, Ling,Guo, Lin,et al. c-Jun as a one-way valve at the naive to primed interface[J]. CELL AND BIOSCIENCE,2023,13(1).
APA
Li, Dongwei.,Luo, Ling.,Guo, Lin.,Wu, Chuman.,Zhang, Ran.,...&Pei, Duanqing.(2023).c-Jun as a one-way valve at the naive to primed interface.CELL AND BIOSCIENCE,13(1).
MLA
Li, Dongwei,et al."c-Jun as a one-way valve at the naive to primed interface".CELL AND BIOSCIENCE 13.1(2023).
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