| Title | Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions |
| Author | |
| Corresponding Author | Yao, Mingxi; Cox, Charles D. |
| Publication Years | 2023-09-01
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| DOI | |
| Source Title | |
| ISSN | 0300-5127
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| EISSN | 1470-8752
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| Abstract | Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory crosstalk between FAs and PIEZO1 channels with the molecular mechanisms underlying this process remaining unclear. However, an emerging picture is developing based on spatial crosstalk between FAs and PIEZO1 revealing a synergistic model involving the cytoskeleton, extracellular matrix (ECM) and calcium-dependent signaling. Already cell type, cell contractility, integrin subtypes and ECM composition have been shown to regulate this crosstalk, implying a highly fine-tuned relationship between these two major mechanosensing systems. In this review, we summarize the latest advances in this area, highlight the physiological implications of this crosstalk and identify gaps in our knowledge that will improve our understanding of cellular mechanosensing. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
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| WOS Research Area | Biochemistry & Molecular Biology
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| WOS Subject | Biochemistry & Molecular Biology
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| WOS Accession No | WOS:001079729300001
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| Publisher | |
| ESI Research Field | BIOLOGY & BIOCHEMISTRY
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| Data Source | Web of Science
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| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/582984 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Victor Chang Cardiac Res Inst, Sydney, NSW 2010, Australia 2.Univ New South Wales, Fac Med & Hlth, Sch Clin Med, Kensington, NSW 2052, Australia 3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China 5.Univ New South Wales, Fac Med & Hlth, Sch Biomed Sci, Kensington, NSW 2052, Australia |
| Corresponding Author Affilication | Department of Biomedical Engineering; Southern University of Science and Technology |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Cheng, Delfine,Wang, Junfan,Yao, Mingxi,et al. Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions[J]. BIOCHEMICAL SOCIETY TRANSACTIONS,2023.
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| APA |
Cheng, Delfine,Wang, Junfan,Yao, Mingxi,&Cox, Charles D..(2023).Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions.BIOCHEMICAL SOCIETY TRANSACTIONS.
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| MLA |
Cheng, Delfine,et al."Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions".BIOCHEMICAL SOCIETY TRANSACTIONS (2023).
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