Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease

Zhu, Min-zheng1; Yang, Mei-feng2; Song, Yang9; Xu, Hao-ming1; Xu, Jing1; Yue, Ning-ning3; Zhang, Yuan4; Tian, Cheng-mei5,6; Shi, Rui-yue8,9; Liang, Yu-jie7; Yao, Jun8,9; Wang, Li-sheng6,8,9; Nie, Yu-qiang1; Li, De-feng8,9

2023-09-01

10.1016/j.biopha.2023.115266

BIOMEDICINE & PHARMACOTHERAPY   Impact Factor & Quartile

0753-3322

1950-6007

Inflammatory bowel disease (IBD) encompasses a collection of idiopathic diseases characterized by chronic inflammation in the gastrointestinal (GI) tract. Patients diagnosed with IBD often experience necessitate long-term pharmacological interventions. Among the multitude of administration routes available for treating IBD, oral administration has gained significant popularity owing to its convenience and widespread utilization. In recent years, there has been extensive evaluation of the efficacy of orally administered herbal medicinal products and their extracts as a means of treating IBD. Consequently, substantial evidence has emerged, supporting their effectiveness in IBD treatment. This review aimed to provide a comprehensive summary of recent studies evaluating the effects of herbal medicinal products in the treatment of IBD. We delved into the regulatory role of these products in modulating immunity and maintaining the integrity of the intestinal epithelial barrier. Additionally, we examined their impact on antioxidant activity, anti-inflammatory properties, and the modulation of intestinal flora. By exploring these aspects, we aimed to emphasize the significant advantages associated with the use of oral herbal medicinal products in the treatment of IBD. Of particular note, this review introduced the concept of herbal plant-derived exosome-like nanoparticles (PDENs) as the active ingredient in herbal medicinal products for the treatment of IBD. The inclusion of PDENs offers distinct advantages, including enhanced tissue penetration and improved physical and chemical stability. These unique attributes not only demonstrate the potential of PDENs but also pave the way for the modernization of herbal medicinal products in IBD treatment.

Inflammatory bowel disease Herbal medicinal products Plant-derived extracellular vesicles Oral administration

SCI

English

Corresponding

Science and Technology Innovation Committee of Shenzhen["JCYJ20190807145617113","JCYJ20210324113802006","JCYJ2022053015180024"] ; Guangdong Basic and Applied Basic Research Foundation["2021A1515010985","2023A1515011936"]

Research & Experimental Medicine ; Pharmacology & Pharmacy

Medicine, Research & Experimental ; Pharmacology & Pharmacy

WOS:001051098900001

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Web of Science

1.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou 510006, Guangdong, Peoples R China
2.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen 518020, Guangdong, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen 518020, Guangdong, Peoples R China
4.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou 516000, Guangdong, Peoples R China
5.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency, Shenzhen 518020, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
7.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen 518020, Guangdong, Peoples R China
8.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen 518020, Guangdong, Peoples R China
9.Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Guangdong, Peoples R China

Zhu, Min-zheng,Yang, Mei-feng,Song, Yang,et al. Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,165.

Zhu, Min-zheng.,Yang, Mei-feng.,Song, Yang.,Xu, Hao-ming.,Xu, Jing.,...&Li, De-feng.(2023).Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease.BIOMEDICINE & PHARMACOTHERAPY,165.

Zhu, Min-zheng,et al."Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease".BIOMEDICINE & PHARMACOTHERAPY 165(2023).