Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy

Ning, Shipeng1; Zhang, Xing6; Suo, Meng3; Lyu, Meng8,9; Pan, You1; Jiang, Yi1; Yang, Huawei1; Lam, Jacky Wing Yip4,5; Zhang, Tianfu3,4,5; Pan, Linghui1,7; Tang, Ben Zhong2,4,5

2023-07-19

10.1016/j.xcrp.2023.101505

CELL REPORTS PHYSICAL SCIENCE   Impact Factor & Quartile

2666-3864

The development of strategies to maintain the long-term presence of reactive oxygen species in tumor sites remains an urgent issue to be addressed. Here, we design platelet exosome hybrid liposome nanovesicles (named platelet-derived exosome hybrid liposomes co-loaded with DPDPy and chloroperoxidase [DCHL]) co-loading ag-gregation-induced emission (AIE) photosensitizers and chloroper-oxidases to facilitate uninterrupted singlet oxygen (1O2) generation for enhancing breast cancer immunotherapy. When DCHL enters tu-mor cells, it lyses under external laser irradiation, thus releasing AIE photosensitizers (DPDPy) and chloroperoxidase. Subsequently, chloroperoxidase utilizes hydrogen peroxide (H2O2) and chloride to synthesize HClO, and, as a second step, HClO reacts with H2O2 to form 1O2. Therefore, uninterrupted 1O2 generation is achieved. The experimental results show that DCHL plus light can lead to sys-temic immune response, increase the proportion of central memory T cells and tumor-infiltrating T cells, and thereby delay tumor recur-rence and rechallenge. Overall, the DCHL system provides a good idea for the design of tumor treatment system.

SCI

English

Others

Guangxi Natural Science Foundation[2023GXNSFBA026137] ; Guangxi Clinical Research Center for Anesthesiology[GK AD22035214] ; Shenzhen Key Laboratory of Functional Aggregate Materials[ZDSYS20211021111400001] ; Science, Technology and Innovation Commission of Shenzhen Municipality["KQTD20210811090142053","JCYJ20220818103007014"]

Chemistry ; Energy & Fuels ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Energy & Fuels ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary

WOS:001048421500001

CELL PRESS

Web of Science

1.Guangxi Med Univ Canc Hosp, Nanning 530000, Peoples R China
2.Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen Inst Aggregate Sci & Technol, Shenzhen 518172, Guangdong, Peoples R China
3.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou 514436, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong Branch, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Clear Water Bay, Hong Kong, Peoples R China
5.Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
6.Univ Hosp RWTH Aachen, Dept Orthoped Trauma & Reconstruct Surg, D-52074 Aachen, Germany
7.Guangxi Engn Res Ctr Tissue & Organ Injury & Repai, Nanning 530000, Peoples R China
8.Southern Univ Sci & Technol, Dept Gastrointestinal Surg, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
9.Jinan Univ, Dept Geriatr, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China

Ning, Shipeng,Zhang, Xing,Suo, Meng,et al. Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy[J]. CELL REPORTS PHYSICAL SCIENCE,2023,4(7).

Ning, Shipeng.,Zhang, Xing.,Suo, Meng.,Lyu, Meng.,Pan, You.,...&Tang, Ben Zhong.(2023).Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy.CELL REPORTS PHYSICAL SCIENCE,4(7).

Ning, Shipeng,et al."Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy".CELL REPORTS PHYSICAL SCIENCE 4.7(2023).