| Title | Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway |
| Author | |
| Corresponding Author | Xu, Shihai; Gong, Ping |
| Publication Years | 2023-08-01
|
| DOI | |
| Source Title | |
| ISSN | 1937-5387
|
| EISSN | 1937-5395
|
| Abstract | Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms. An in vivo rat model of I/R after AMI induction was established through the ligation of the left anterior descending (LAD) artery to assess the cardiac functions and evaluate the protective effect of protectin D1. Protectin D1 protected against I/R-induced oxidative stress and inflammation in the rat model, improved the cardiac function, and reduced the infarct size in myocardial tissues. The beneficial effect of protectin D1 was associated with the up-regulation of miRNA-210 and the effects on PI3K/AKT signaling and HIF-1a expression. Together, our data suggest that protectin D1 could serve as a potential cardioprotective agent against I/R-associated cardiac defects. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Science and Technology Innovation Foundation of Shenzhen[JCYJ20190806150005453]
|
| WOS Research Area | Cardiovascular System & Cardiology
; Research & Experimental Medicine
|
| WOS Subject | Cardiac & Cardiovascular Systems
; Medicine, Research & Experimental
|
| WOS Accession No | WOS:001050294600001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/583031 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Cardiol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Emergency Dept,Affiliated Hosp 1,Clin Med Coll 2, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China 3.Shouxian Chinese Med Hosp, Dept Anesthesiol, Huainan 232299, Anhui, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| First Author's First Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Zhang, Peng,Wang, Jin,Wang, Xingsong,et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway[J]. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH,2023.
|
| APA |
Zhang, Peng,Wang, Jin,Wang, Xingsong,Wang, Li,Xu, Shihai,&Gong, Ping.(2023).Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway.JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH.
|
| MLA |
Zhang, Peng,et al."Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway".JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2023).
|
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