A 5-Year Follow-Up Study to Explore Factors Associated with Rapid Kidney Function Decline Among Bus Drivers

Wu, Yanxia1; Chen, Qianqian2; Zhang, Qionghua1; Wu, Yanli3; Zheng, Xujuan2,4

2023

10.2147/IJGM.S419098

INTERNATIONAL JOURNAL OF GENERAL MEDICINE   Impact Factor & Quartile

1178-7074

Background: Owing to the stressful occupational characteristics, bus drivers have been reported to have a higher risk of renal dysfunction. However, the related factors associated with rapid kidney function decline among bus drivers have not been explored in the existing literature. Therefore, our research aimed to investigate factors related with rapid kidney function decline, and to explore the correlation of baseline SUA (serum uric acid), longitudinal changes in SUA, and rapid eGFR (estimated glomerular filtration rate) decline for bus drivers.Methods: This was a five-year cohort study in Shenzhen, China, between 2017 and 2021. We included 832 bus drivers with normal kidney function at baseline. Study subjects were stratified into four quartiles of change in eGFR, and rapid eGFR decline was regarded as the highest (4th) quartile of & UDelta;eGFR (eGFR in 2017-eGFR in 2021). Univariable and multivariable logistic regressions were conducted to explore factors affecting rapid eGFR decline.Results: The incidence of hyperuricemia among bus drivers was 37.7% in 2017 and 40.5% in 2021. The overall subjects had a median 5-year decrease in eGFR of 6.72 mL/min/1.73 m2, and individuals with increased SUA from normal to hyperuricemia group had the greatest decline of eGFR. Multivariate analysis showed bus drivers' age (Odds radio: OR, 1.04), elevated baseline eGFR (OR, 1.08), and SUA increase (OR, 1.38) were significantly associated with rapid eGFR changes.Conclusion: The high prevalence of hyperuricemia among bus drivers should warrant more attention from health professionals. Subjects' age, elevated baseline eGFR, and SUA increase were risk factors for rapid eGFR decline over 5-year. The findings can provide significant evidence for timely prevention and intervention to decrease the incidence of rapid renal function decline among bus drivers.

chronic kidney disease risk factors bus driver glomerular filtration rate China

SCI

English

First

General & Internal Medicine

Medicine, General & Internal

WOS:001043218000001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Hlth Management Ctr,Clin Medi C, Shenzhen 518020, Peoples R China
2.Shenzhen Univ, Med Sch, Shenzhen 518060, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Dept Operat Room, Guangzhou 510060, Peoples R China
4.Shenzhen Univ, A1-402 Room, Xili Campus, 1066, Xueyuan Rd, Shenzhen, Guangdong, Peoples R China

Wu, Yanxia,Chen, Qianqian,Zhang, Qionghua,et al. A 5-Year Follow-Up Study to Explore Factors Associated with Rapid Kidney Function Decline Among Bus Drivers[J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE,2023,16.

Wu, Yanxia,Chen, Qianqian,Zhang, Qionghua,Wu, Yanli,&Zheng, Xujuan.(2023).A 5-Year Follow-Up Study to Explore Factors Associated with Rapid Kidney Function Decline Among Bus Drivers.INTERNATIONAL JOURNAL OF GENERAL MEDICINE,16.

Wu, Yanxia,et al."A 5-Year Follow-Up Study to Explore Factors Associated with Rapid Kidney Function Decline Among Bus Drivers".INTERNATIONAL JOURNAL OF GENERAL MEDICINE 16(2023).