| Title | Diagnostic value of aberrant decreased 5-Methylcytosine RNA modification in leukocytes for non-small cell lung cancer |
| Author | |
| Corresponding Author | Jiang, Xi; Yin, Haofan; Hong, Honghai |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 1837-9664
|
| Volume | 14Issue:12 |
| Abstract | Background: Non-small cell lung cancer (NSCLC) was a disease with poor outcomes, partly because there were no high-efficiency non-invasive diagnostic biomarkers. The RNA modification status of 5-Methylcytosine (m5C) has been shown to be a biomarker for various diseases, but its potentiality to be a diagnostic biomarker for NSCLC remained inconclusive. Methods: In this research, we collected peripheral leukocyte samples from 141 patients with NSCLC and 90 normal people as controls to evaluate the extent of m5C RNA modification. Results: We found that the m5C modification levels in leukocytes of NSCLC patients were decreased dramatically, which were compared to the normal controls, and levels of m5C modification decreased progressively with tumor stage. Importantly, m5C modification exhibited superior diagnostic value compared to carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), and carbohydrate antigen 125 (CA125), which demonstrated area under the curves (AUCs) of 0.912, 0.773, 0.669, 0.754, and 0.732, respectively. The combination of m5C modification with these serum tumor biomarkers further improved the AUC to 0.960. A nomogram model incorporating m5C modification also provided an effectively diagnostic tool for NSCLC. Conclusion: Collectively, our findings suggested that m5C modification in leukocytes held promise as a prospective biomarker for NSCLC diagnosis. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Nature Science Foundation of China["81902693","82103346","82202829"]
; Guangdong Basic and Applied Basic Research Foundation["2021A15151 10094","2022A1515111199"]
|
| WOS Research Area | Oncology
|
| WOS Subject | Oncology
|
| WOS Accession No | WOS:001040943000006
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/583047 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Jinan Univ, Zhuhai Peoples Hosp, Dept Clin Lab, Zhuhai Hosp, Zhuhai, Guangdong, Peoples R China 2.Guangzhou Med Univ, Dept Clin Lab, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China 3.Jinan Univ, Shenzhen Peoples Hosp The Clin Med Coll 2, Dept Med Lab, Shenzhen, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China 5.South China Univ Technol, Guangzhou People Hosp 1, Sch Med, Dept Clin Med Lab, Guangzhou, Guangdong, Peoples R China 6.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Huang, Mao,Ming, Liang,Jiang, Hongbo,et al. Diagnostic value of aberrant decreased 5-Methylcytosine RNA modification in leukocytes for non-small cell lung cancer[J]. JOURNAL OF CANCER,2023,14(12).
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| APA |
Huang, Mao.,Ming, Liang.,Jiang, Hongbo.,Jiang, Ping.,Jiang, Xi.,...&Hong, Honghai.(2023).Diagnostic value of aberrant decreased 5-Methylcytosine RNA modification in leukocytes for non-small cell lung cancer.JOURNAL OF CANCER,14(12).
|
| MLA |
Huang, Mao,et al."Diagnostic value of aberrant decreased 5-Methylcytosine RNA modification in leukocytes for non-small cell lung cancer".JOURNAL OF CANCER 14.12(2023).
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