Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function

Hang, Hai Z.1; Zeng, Si-lue2,3; Wu, Yun-zhu1,3,4; Zhang, Ruo-xin5; Liu, Liang-jian3; Xue, Qiang1,3; Chen, Jing -Qin3; Wong, Kenneth K. Y.6; Xu, Jin-feng1; Ren, Ya-guang3; Fang, Chi-hua2; Liu, Cheng-bo3

2023-07-01

10.1364/BOE.493538

BIOMEDICAL OPTICS EXPRESS   Impact Factor & Quartile

2156-7085

Preoperative assessment of liver function reserve (LFR) is essential for determining the extent of liver resection and predicting the prognosis of patients with liver disease. In this paper, we present a real-time, handheld photoacoustic imaging (PAI) system-based noninvasive approach for rapid LFR assessment. A linear-array ultrasound transducer was sealed in a housing filled with water; its front end was covered with a plastic wrap. This PAI system was first implemented on phantoms to confirm that the photoacoustic (PA) intensity of indocyanine green (ICG) in blood reflects the concentration of ICG in blood. In vivo studies on normal rabbits and rabbits with liver fibrosis were carried out by recording the dynamic PA signal of ICG in their jugular veins. By analyzing the PA intensity-time curve, a clear difference was identified in the pharmacokinetic behavior of ICG between the two groups. In normal rabbits, the mean ICG clearance rate obtained by PAI at 15 min after administration (PAI-R15) was below 21.6%, whereas in rabbits with liver fibrosis, PAI-R15 exceeded 62.0% because of poor liver metabolism. The effectiveness of the proposed method was further validated by the conventional ICG clearance test and pathological examination. Our findings suggest that PAI is a rapid, noninvasive, and convenient method for LFR assessment and has immense potential for assisting clinicians in diagnosing and managing patients with liver disease.

SCI

English

First

National Natural Science Foundation of China["2016YFC0106500","2020YFA0908800","2021YFE0202200","2022YFE0132300"] ; NSFC-GD Union Foundation["12026602","62105355","81627805","81927807","82122034","92059108"] ; Chinese Academy of Sciences Grant[U1401254] ; Shenzhen Science and Technology Innovation Grant["2019352","GJJSTD20210003"] ; CAS Key Laboratory of Health Informatics[JCYJ20220818101403008] ; Guangdong Provincial Key Laboratory of Biomedical Optical Imaging[2011DP173015] ; Shenzhen Key Laboratory for Molecular Imaging[2020B121201010] ; Basic and Applied Basic Research Foundation of Guangdong Province[ZDSY20130401165820357] ; Natural Science Foundation of Shenzhen City["2019A1515110727","2020A1515010978"] ; null[JCYJ20190806150001764]

Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

WOS:001037183300006

Optica Publishing Group

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Ultrasound,Clin Coll 2,Affiliated Hosp 1, Shenzhen 518020, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg 1, Guangzhou 510280, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Lab Biomed Opt & Mol Imaging, CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China
4.Sichuan Univ, West China Univ Hosp 2, Dept Ultrasound, Chengdu 610044, Sichuan, Peoples R China
5.Shen Zhen Bay Lab, Shenzhen 518000, Peoples R China
6.Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong, Peoples R China

Hang, Hai Z.,Zeng, Si-lue,Wu, Yun-zhu,et al. Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function[J]. BIOMEDICAL OPTICS EXPRESS,2023,14(7).

Hang, Hai Z..,Zeng, Si-lue.,Wu, Yun-zhu.,Zhang, Ruo-xin.,Liu, Liang-jian.,...&Liu, Cheng-bo.(2023).Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function.BIOMEDICAL OPTICS EXPRESS,14(7).

Hang, Hai Z.,et al."Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function".BIOMEDICAL OPTICS EXPRESS 14.7(2023).