Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue, Ning-ning1; Xu, Hao-ming2; Xu, Jing2; Zhu, Min-zheng3; Zhang, Yuan4; Tian, Cheng-Mei5; Nie, Yu-qiang2; Yao, Jun1; Liang, Yu-jie6; Li, De-feng1,7; Wang, Li-sheng1,7

2023

10.2147/IJN.S413141

INTERNATIONAL JOURNAL OF NANOMEDICINE   Impact Factor & Quartile

1178-2013

The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these procedures can cause discomfort, respiratory issues, and bacterial infections in patients, both during and after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements in diagnostic techniques. Nanoprobes, in particular, offer distinct advantages, such as high specificity and sensitivity in detecting GI diseases. Integration of nanoprobes with advanced imaging techniques, such as nuclear magnetic resonance, optical fluorescence imaging, tomography, and optical correlation tomography, has significantly enhanced the detection capabilities for GI tumors and inflammatory bowel disease (IBD). This synergy enables early diagnosis and precise staging of GI disorders. Among the nanoparticles investigated for clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, and nanocages have emerged as extensively studied and utilized agents. This review aimed to provide insights into the potential applications of nanoparticles in modern imaging techniques, with a specific focus on their role in facilitating early and specific diagnosis of a range of GI disorders, including IBD and colorectal cancer (CRC). Additionally, we discussed the challenges associated with the implementation of nanotechnology-based GI diagnostics and explored future prospects for translation in this promising field.

nano-diagnostics imaging gastroenterology gastrointestinal tumor inflammatory bowel disease

SCI

English

Corresponding

Science and Technology Innovation Committee of Shenzhen["JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ20210324113802006"] ; Technical Research and Development Project of Shenzhen[JCYJ2022053015180024] ; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK042]

Science & Technology - Other Topics ; Pharmacology & Pharmacy

Nanoscience & Nanotechnology ; Pharmacology & Pharmacy

WOS:001040140800001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen, Guangdong, Peoples R China
2.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou, Peoples R China
3.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China
4.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China
5.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency, Shenzhen, Guangdong, Peoples R China
6.Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, Shenzhen, Guangdong, Peoples R China
7.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Gastroenterol,Affiliated Hosp 1,Clin Med Coll, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China

Yue, Ning-ning,Xu, Hao-ming,Xu, Jing,et al. Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2023,18.

Yue, Ning-ning.,Xu, Hao-ming.,Xu, Jing.,Zhu, Min-zheng.,Zhang, Yuan.,...&Wang, Li-sheng.(2023).Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective.INTERNATIONAL JOURNAL OF NANOMEDICINE,18.

Yue, Ning-ning,et al."Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective".INTERNATIONAL JOURNAL OF NANOMEDICINE 18(2023).