| Title | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| Author | |
| Corresponding Author | Qiu, Chong; Guo, Qiuyan; Wang, Jigang |
| Publication Years | 2023-05-24
|
| DOI | |
| Source Title | |
| ISSN | 2096-5168
|
| EISSN | 2639-5274
|
| Volume | 6 |
| Abstract | Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, smallmolecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/ lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | Fundamental Research Funds for the National Natural Science Foundation["82204322","82104480"]
; Central Public Welfare Research Institutes["ZZ16-ND-10-05","ZZ16-ND-10-13","ZZ16-ND-10-17","ZZ16-ND-10-19","ZZ14-YQ-050","ZZ14-YQ-055","ZZ14-YQ-059","ZZ14-YQ-060","ZZ16-YQ-046"]
; Young Elite Scientists Sponsorship Program by CACM[2021QNRC2B29]
|
| WOS Research Area | Science & Technology - Other Topics
|
| WOS Subject | Multidisciplinary Sciences
|
| WOS Accession No | WOS:001001555900001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/583086 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Nephrol, Shenzhen 518020, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Guangdong, Peoples R China |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Qiu, Chong,Xia, Fei,Zhang, Junzhe,et al. Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery[J]. RESEARCH,2023,6.
|
| APA |
Qiu, Chong.,Xia, Fei.,Zhang, Junzhe.,Shi, Qiaoli.,Meng, Yuqing.,...&Wang, Jigang.(2023).Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery.RESEARCH,6.
|
| MLA |
Qiu, Chong,et al."Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery".RESEARCH 6(2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
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