Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges

Tian, Cheng-Mei1,2; Zhang, Yuan3; Yang, Mei-Feng4; Xu, Hao-Ming5; Zhu, Min-Zheng6; Yao, Jun1; Wang, Li-Sheng1,8; Liang, Yu-Jie7; Li, De-Feng1,8

2023

10.2147/JIR.S400447Journal

JOURNAL OF INFLAMMATION RESEARCH   Impact Factor & Quartile

1178-7031

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a group of chronic inflammatory diseases of the gastrointestinal tract. Repeated inflammation can lead to complications, such as intestinal fistula, obstruction, perforation, and bleeding. Unfortunately, achieving durable remission and mucosal healing (MH) with current treatments is difficult. Stem cells (SCs) have the potential to modulate immunity, suppress inflammation, and have anti-apoptotic and proangiogenic effects, making them an ideal therapeutic strategy to target chronic inflammation and intestinal damage in IBD. In recent years, hematopoietic stem cells (HSCs) and adult mesenchymal stem cells (MSCs) have shown efficacy in treating IBD. In addition, numerous clinical trials have evaluated the efficiency of MSCs in treating the disease. This review summarizes the current research progress on the safety and efficacy of SC-based therapy for IBD in both preclinical models and clinical trials. We discuss potential mechanisms of SC therapy, including tissue repair, paracrine effects, and the promotion of angiogenesis, immune regulation, and antiinflammatory effects. We also summarize current SC engineering strategies aimed at enhancing the immunosuppressive and regenerative capabilities of SCs for treating intestinal diseases. Additionally, we highlight current limitations and future perspectives of SC-related therapy for IBD.

stem cells mesenchymal stromal cells HSCs immunosuppression inflammatory bowel disease ulcerative colitis Crohn's disease

SCI

English

First ; Corresponding

Science and Technology Innovation Committee of Shenzhen["JCYJ20200109150700942","JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ2021 0324113802006"] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515011581] ; National Natural Science Foundation of China[81800489]

Immunology

Immunology

WOS:000993986800001

DOVE MEDICAL PRESS LTD

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Gastroenter, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Emergency,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
3.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China
4.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China
5.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China
6.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China
7.Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, Shenzhen, Guangdong, Peoples R China
8.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Gastroenter, 1017,Dongmen North Rd, Shenzhen 518020, Peoples R China

Tian, Cheng-Mei,Zhang, Yuan,Yang, Mei-Feng,et al. Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges[J]. JOURNAL OF INFLAMMATION RESEARCH,2023,16.

Tian, Cheng-Mei.,Zhang, Yuan.,Yang, Mei-Feng.,Xu, Hao-Ming.,Zhu, Min-Zheng.,...&Li, De-Feng.(2023).Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges.JOURNAL OF INFLAMMATION RESEARCH,16.

Tian, Cheng-Mei,et al."Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges".JOURNAL OF INFLAMMATION RESEARCH 16(2023).