Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy

Ji, Pengchao1,3,4; Chen, Jinghua3; Wang, Hao1,4,5; Shi, Linfei2; Tang, Xudong1,7; Duo, Yanhong1,6,7

2023-06-27

10.1039/d3bm00206c

BIOMATERIALS SCIENCE   Impact Factor & Quartile

2047-4830

2047-4849

Many approaches have been employed to relieve hypoxia in solid tumors to enhance sensitivity to radiotherapy (RT), including O-2 delivery or hydrogen peroxide (H2O2) decomposition strategies. To date, however, these modalities have been restricted by poor O-2 loading, rapid O-2 leakage, and limited endogenous H2O2 levels. To overcome these limitations, we therefore sought to develop an effective approach for the oxygen-independent treatment of hypoxic tumors. In this study, we designed a novel black phosphorus quantum dot (BPQD)/Escherichia coli (E. coli) hybrid system (BE) capable of facilitating the photothermal therapy (PTT) of hypoxic tumors. A simple electrostatic adsorption approach was used to conjugate BPQDs to E. coli. BE is capable of reliably targeting hypoxic tumors and mediating PTT. BPQDs in BE can directly facilitate X-ray-mediated radiosensitization of tumors, thereby achieving significant RT efficacy in response to lower doses of radiation, effectively and specifically damaging hypoxic tumor tissues to suppress the growth of tumors. Our results highlight this BE system as a novel approach to tumor radiosensitization with great potential for clinical application.

SCI

English

Others

Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20190808154213097] ; Natural Science Foundation of Guangdong Province[2020A1515010400]

Materials Science

Materials Science, Biomaterials

WOS:000996787300001

ROYAL SOC CHEMISTRY

Web of Science

1.Tsinghua Univ Shenzhen, Res Inst, Key Lab New Drug Res TCM, Shenzhen 518057, Guangdong, Peoples R China
2.Qing Hai Ctr Dis Prevent & Control, Xining 810007, Qinghai, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Med Oncol, Shenzhen 518020, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Guangdong Engn T, Shenzhen 518020, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Neurosurg,Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
6.Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden
7.Dalian Univ Technol, Sch Chem Engn, Dept Pharmacol, State Key Lab Fine Chem, Dalian, Peoples R China

Ji, Pengchao,Chen, Jinghua,Wang, Hao,et al. Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy[J]. BIOMATERIALS SCIENCE,2023,11(13).

Ji, Pengchao,Chen, Jinghua,Wang, Hao,Shi, Linfei,Tang, Xudong,&Duo, Yanhong.(2023).Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy.BIOMATERIALS SCIENCE,11(13).

Ji, Pengchao,et al."Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy".BIOMATERIALS SCIENCE 11.13(2023).