Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study

Liang, Yannis Yan1,2,3; Chen, Yilin1,4; Feng, Hongliang1,5; Liu, Xiangxin5,6; Ai, Qi-Yong H.7; Xue, Huachen8; Shu, Xinyue9; Weng, Foqian9; He, Zhixuan9; Ma, Jiacheng8; Ma, Huan1,2; Ai, Sizhi10; Geng, Qingshan1,12; Zhang, Jihui8,13,14

2023-03-01

10.1016/j.jchf.2022.11.028

JACC-HEART FAILURE   Impact Factor & Quartile

2213-1779

2213-1787

BACKGROUND Social isolation and loneliness have emerged as important risk factors for cardiovascular diseases, particularly during the coronavirus disease pandemic. However, it is unclear whether social isolation and loneliness had independent and joint associations with incident heart failure (HF). OBJECTIVES This study sought to examine the association of social isolation, loneliness, and their combination with incident HF. METHODS The UK Biobank study is a population-based cohort study. Social isolation and loneliness were assessed using self-reported questionnaires. HF cases were identified by linking hospital records and death registries. The weighted polygenic risk score associated with HF was calculated. RESULTS Among the 464,773 participants (mean age: 56.5 +/- 8.1 years, 45.3% male), 12,898 incident HF cases were documented during a median follow-up of 12.3 years. Social isolation (most vs least: adjusted HR: 1.17; 95% CI:1.11-1.23) and loneliness (yes vs no: adjusted HR: 1.19; 95% CI: 1.11-1.27) were significantly associated with an increased risk of incident HF. The association between an elevated risk of HF and social isolation was modified by loneliness (Pinteraction 1/4 0.034). A gradient of association between social isolation and the risk of incident HF was found only among individuals without loneliness (Ptrend < 0.001), but not among those with loneliness (Ptrend 1/4 0.829). These associations were independent of the genetic risk of HF. CONCLUSIONS Social isolation and loneliness were independently associated with a higher likelihood of incident HF regardless of genetic risk. The association between social isolation and incident HF was potentially modified by loneliness status. (J Am Coll Cardiol HF 2023;11:334-344) (c) 2023 by the American College of Cardiology Foundation.

genetic predisposition to disease heart failure loneliness social isolation UK Biobank

SCI

English

Corresponding

National Natural Science Foundation of China["32100880","59117"]

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:000990080400001

ELSEVIER SCI LTD

Web of Science

1.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou, Guangdong, Peoples R China
3.Jinan Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Guangdong, Peoples R China
4.South China Univ Technol, Sch Med, Guangzhou, Guangdong, Peoples R China
5.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China
6.First Peoples Hosp Kashi Reg, Dept Psychol Med, Kashi, Xinjiang, Peoples R China
7.Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hung Hom, Kowloon, Hong Kong, Peoples R China
8.Guangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou, Guangdong, Peoples R China
9.Jinan Univ, Sch Med, Guangzhou, Guangdong, Peoples R China
10.Xinxiang Med Univ, Affiliated Hosp 1, Heart Ctr, Dept Cardiol, Weihui, Henan, Peoples R China
11.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Geriatr, Guangzhou, Peoples R China
12.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
13.Guangzhou Med Univ, Key Lab Neurogenet & Channelopathies Guangdong Pro, Guangzhou, Guangdong, Peoples R China
14.Guangzhou Med Univ, Minist Educ China, Guangzhou, Guangdong, Peoples R China

Liang, Yannis Yan,Chen, Yilin,Feng, Hongliang,et al. Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study[J]. JACC-HEART FAILURE,2023,11(3).

Liang, Yannis Yan.,Chen, Yilin.,Feng, Hongliang.,Liu, Xiangxin.,Ai, Qi-Yong H..,...&Zhang, Jihui.(2023).Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study.JACC-HEART FAILURE,11(3).

Liang, Yannis Yan,et al."Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study".JACC-HEART FAILURE 11.3(2023).