| Title | Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis |
| Author | |
| Corresponding Author | Lu, Hongzhou |
| Publication Years | 2023-03-01
|
| DOI | |
| Source Title | |
| ISSN | 1881-7831
|
| EISSN | 1881-784X
|
| Abstract | Tuberculosis (TB) is a major public health problem that causes millions of deaths in humans around the world, and the bacterial pathogen Mycobacterium tuberculosis (Mtb) is responsible for this disease. Evidence suggested that the inflammasome-pyroptosis pathway is crucial for preventing Mtb infection. Uncertainty exists regarding whether and how these infections can bypass this immune system by Mtb. A recent Science article by Chai et al. (doi: 10.1126/science.abq0132) revealed a novel role by a eukaryotic-like effector called PtpB during Mtb infection. The PtpB functions as a phospholipid phosphatase suppressing gasdermin D (GSDMD) dependent pyroptosis. And notably, the phospholipid phosphatase activity of PtpB is dependent on binding with mono-ubiquitin (Ub) of the host. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Shenzhen Scientific and Technological Foundation[KCXFZ20211020163 545004]
; Guangdong Scientific and Technological Foundation["556 2019B1515120041","2020B1111170014"]
|
| WOS Research Area | Pharmacology & Pharmacy
|
| WOS Subject | Pharmacology & Pharmacy
|
| WOS Accession No | WOS:000963602700001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics | |
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/583135 |
| Department | The Third People's Hospital of Shenzhen 南方科技大学第一附属医院 |
| Affiliation | 1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Guangdong Prov Clin Res Ctr TB, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China |
| First Author Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
| Corresponding Author Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
| First Author's First Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Feng, Qishun,Zhang, Guoliang,Lu, Hongzhou. Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis[J]. DRUG DISCOVERIES AND THERAPEUTICS,2023.
|
| APA |
Feng, Qishun,Zhang, Guoliang,&Lu, Hongzhou.(2023).Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis.DRUG DISCOVERIES AND THERAPEUTICS.
|
| MLA |
Feng, Qishun,et al."Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis".DRUG DISCOVERIES AND THERAPEUTICS (2023).
|
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