Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections

Tan, Qingqin1; Chen, Zhenxing2,3,4; Liu, Lei1; Huang, Xi1,2,3

2023-07-01

10.1002/adhm.202203200

ADVANCED HEALTHCARE MATERIALS   Impact Factor & Quartile

2192-2640

2192-2659

Skin and soft tissue infections (SSTIs) are among the most common bacterial infections reported in outpatients. Drug-resistant bacteria are the major cause of treatment failure and increased mortality rate in patients with SSTIs, posing significant challenges to human health. In this study, new-generation rhodium nanoplates (RhNPs) and glycol chitosan- and polydopamine-functionalized RhNPs (Rh@GCS) are developed for the treatment of drug-resistant SSTIs. RhNPs exhibited favorable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Ag-resistant MRSA. The modified Rh@GCS exhibited enhanced antibacterial activity and can directly kill various drug-resistant bacteria by increasing the permeability of cell membranes, including gram-positive MRSA and gram-negative multidrug-resistant Escherichia coli (E.coli) and Pseudomonas aeruginosa (PA). Moreover, Rh@GCS effectively inhibited bacterial growth and promoted the healing of skin lesions in MRSA-induced SSTI mouse models. These results suggest that Rh@GCS is a promising nonantibiotic antimicrobial agent for the treatment of drug-resistant SSTIs.

antibacterial activity drug-resistant bacteria rhodium nanoparticles skin and soft tissue infections

SCI

English

First ; Corresponding

National Natural Science Foundation of China[82072062] ; National Science and Technology Key Projects for Major Infectious Diseases[2017ZX10302301-002] ; Development Project of Foshan Fourth People's Hospital["FSSYKF-2020003","FSSYKF-2020017"] ; Department of Science and Technology of Guangdong Province to the Guangdong Provincial Key Laboratory of Biomedical Imaging[2018B030322006]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000963124900001

WILEY

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Shenzhen 518112, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 5, Ctr Infect & Immun, Zhuhai 519000, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 5, Guangdong Prov Key Lab Biomed Imaging, Zhuhai 519000, Guangdong, Peoples R China
4.Kingcell Regenerat Med Guangdong Co, Zhuhai 519000, Guangdong, Peoples R China

Tan, Qingqin,Chen, Zhenxing,Liu, Lei,et al. Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections[J]. ADVANCED HEALTHCARE MATERIALS,2023,12(19).

Tan, Qingqin,Chen, Zhenxing,Liu, Lei,&Huang, Xi.(2023).Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections.ADVANCED HEALTHCARE MATERIALS,12(19).

Tan, Qingqin,et al."Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections".ADVANCED HEALTHCARE MATERIALS 12.19(2023).