A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy

Ning, Shipeng1,8,9; Zhang, Tianfu3,4,5; Lyu, Meng10,11; Lam, Jacky Wing Yip4,5; Zhu, Daoming6,7; Huang, Qinqin1; Tang, Ben Zhong2,4,5

2023-04-01

10.1016/j.biomaterials.2023.122034

BIOMATERIALS   Impact Factor & Quartile

0142-9612

1878-5905

Radioresistance of Cancer stem cell (CSC) is an important cause of tumor recurrence after radiotherapy (RT). Herein, we designed a type I aggregation-induced emission (AIE) photosensitiser-loaded biomimetic mesoporous organosilicon nanosystem (PMT) for precise depletion of CSC to prevent tumor recurrence after RT. This PMT system is composed of a type I AIE photosensitiser (TBP-2) loaded mesoporous organosilicon nanoparticles (MON) with an outer platelet membrane. The PMT system is able to specifically target CSC. Intracellular glutathione activity leads to MON degradation and the release of TBP-2. Type I photodynamic therapy is activated by exposure to white light, producing a large amount of hydroxyl radicals to promote CSC death. The results of in vivo experiments demonstrated specific removal of CSC following PMT treatment, with no tumor recurrence observed when combined with RT. However, tumor recurrence was observed in mice that received RT only. The expression of CSC markers was significantly reduced following PMT treatment. We demonstrate the development of a system for the precise removal of CSC with good biosafety and high potential for clinical translation. We believe the PMT nanosystem represents a novel idea in the prevention of tumor recurrence.

Tumor recurrence after radiotherapy Type I photodynamic therapy Precise depletion of cancer stem cells Platelet biomimetic nanosystem GSH depletion

SCI

English

Others

Guangxi Clinical Research Center for Anesthesiology[GK 22035214] ; Cultivation of High-level Internationalized Talents Project[22180007] ; Medical Science and Technology Co -construction Project of Henan Province[LHGJ20190326]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000963771600001

ELSEVIER SCI LTD

MATERIALS SCIENCE

Web of Science

1.Zhengzhou Univ, Affiliated Hosp 2, Res & Applicat Ctr Precis Med, Zhengzhou, Peoples R China
2.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
3.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou, Peoples R China
4.Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem, Hong Kong Branch, Hong Kong Univ Sci & Technol Clear Water Bay, Hong Kong 999077, Peoples R China
5.Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
6.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China
7.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Guangdong, Peoples R China
8.Guangxi Med Univ Canc Hosp, Dept Breast Surg, Nanning 530000, Peoples R China
9.Guangxi Clin Res Ctr Anesthesiol, Nanning 530000, Peoples R China
10.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Gastroi, Shenzhen 518020, Guangdong, Peoples R China
11.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Geriatr, Shenzhen 518020, Guangdong, Peoples R China

Ning, Shipeng,Zhang, Tianfu,Lyu, Meng,et al. A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy[J]. BIOMATERIALS,2023,295.

Ning, Shipeng.,Zhang, Tianfu.,Lyu, Meng.,Lam, Jacky Wing Yip.,Zhu, Daoming.,...&Tang, Ben Zhong.(2023).A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy.BIOMATERIALS,295.

Ning, Shipeng,et al."A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy".BIOMATERIALS 295(2023).