Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells

Liu, Xi1,2; Wei, Qian1,2; Lu, Lu3; Cui, Shengnan1,2,4; Ma, Kui1,2,5; Zhang, Wenhua1,2; Ma, Fang6; Li, Haihong7; Fu, Xiaobing1,2,5; Zhang, Cuiping1,2,5

2023-02-13

10.3389/fimmu.2023.1094685

FRONTIERS IN IMMUNOLOGY   Impact Factor & Quartile

1664-3224

Various intractable inflammatory diseases caused by disorders of immune systems have pressed heavily on public health. Innate and adaptive immune cells as well as secreted cytokines and chemokines are commanders to mediate our immune systems. Therefore, restoring normal immunomodulatory responses of immune cells is crucial for the treatment of inflammatory diseases. Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are nano-sized double-membraned vesicles acting as paracrine effectors of MSCs. MSC-EVs, containing a variety of therapeutic agents, have shown great potential in immune modulation. Herein, we discuss the novel regulatory functions of MSC-EVs from different sources in the activities of innate and adaptive immune cells like macrophages, granulocytes, mast cells, natural killer (NK) cells, dendritic cells (DCs) and lymphocytes. Then, we summarize the latest clinical trials of MSC-EVs in inflammatory diseases. Furthermore, we prospect the research trend of MSC-EVs in the field of immune modulation. Despite the fact that the research on the role of MSC-EVs in regulating immune cells is in infancy, this cell-free therapy based on MSC-EVs still offers a promising solution for the treatment of inflammatory diseases.

extracellular vesicles mesenchymal stem cells immune cells cell dysfunction inflammatory diseases

SCI

English

Corresponding

National Nature Science Foundation of China["22205260","82172211","81830064","82172231"] ; National Key Research and Development Programs of China[2022YFA1104303] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2019-I2M-5-059] ; Military Medical Research and Development Projects["AWS17J005","2019-126"] ; Military Medical Science and Technology Youth Training Program[21QNPY128]

Immunology

Immunology

WOS:000939552400001

FRONTIERS MEDIA SA

Web of Science

1.Chinese Peoples Liberat Army Gen Hosp, Res Ctr Tissue Repair & Regenerat, Med Innovat Res Div, Beijing, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Beijing, Peoples R China
3.PLA Army, Inst NBC Def, Beijing, Peoples R China
4.China Acad Chinese Med Sci, Xiyuan Hosp, Dept Dermatol, Beijing, Peoples R China
5.Chinese Acad Med Sci, Res Unit Trauma Care Tissue Repair & Regenerat, Beijing, Peoples R China
6.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing, Peoples R China
7.Southern Univ Sci & Technol, Southern Univ Sci & Technol Hosp, Inst Wound Repair & Regenerat Med, Sch Med,Dept Wound Repair, Shenzhen, Peoples R China

Liu, Xi,Wei, Qian,Lu, Lu,et al. Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells[J]. FRONTIERS IN IMMUNOLOGY,2023,14.

Liu, Xi.,Wei, Qian.,Lu, Lu.,Cui, Shengnan.,Ma, Kui.,...&Zhang, Cuiping.(2023).Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells.FRONTIERS IN IMMUNOLOGY,14.

Liu, Xi,et al."Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells".FRONTIERS IN IMMUNOLOGY 14(2023).