Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials

Chen, Jie-Hua1,2; Lu, Louise Weiwei3,7; Ge, Qian4,5; Feng, Dana6; Yu, Jianfeng1,2; Liu, Bin1,2; Zhang, Ruijie1; Zhang, Xinying1; Ouyang, Caiqun4,5; Chen, Feng1,2

2023-06-11

10.1080/10408398.2021.1974335

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION   Impact Factor & Quartile

1040-8398

1549-7852

The efficacy of using time restricted eating (TRE) for weight management and to mitigate metabolic disorders in overweight and obese people remains debatable. This meta-analysis quantified the impact of TRE on weight loss and metabolic health in overweight and obese people. The pooled results were subjected to a random-effects modeling using Hartung-Knapp-Sidik-Jonkman (HKSJ) method. Additionally, subgroup analysis was conducted based on study types, randomized controlled trials (RCTs) vs. non-randomized studies of interventions (NRSIs). Pooled results showed that subjects on TRE regimen (> 4 weeks) achieved a significant weight loss in comparison with unrestricted time regimen (weighted mean difference: -2.32%; 95% CI: -3.50, -1.14%; p < 0.01); however, weight loss was mainly attributed to the loss of lean mass rather than fat mass. The magnitude of weight loss was inversely correlated with daily fasting duration in RCTs. TRE significantly decreased the diastolic blood pressure and fasting insulin. An increase of low-density lipoprotein cholesterol (LDL-C) was observed in the TRE group. Favorable effect of TRE was observed on glucose metabolism but not on lipid profiles independent of weight loss. Hence TRE shall be administered with caution to overweight and obese people who have comorbidities such as dyslipidemia and sarcopenia.

Meta-analysis metabolic health obese overweight time restricted eating weight loss

SCI

English

Corresponding

Food Science & Technology ; Nutrition & Dietetics

Food Science & Technology ; Nutrition & Dietetics

WOS:000698705200001

TAYLOR & FRANCIS INC

AGRICULTURAL SCIENCES

Web of Science

1.Shenzhen Univ, Inst Innovat Dev Food Ind, Shenzhen, Peoples R China
2.Shenzhen Univ, Inst Adv Study, Shenzhen Key Lab Marine Microbiome Engn, Shenzhen, Peoples R China
3.Univ Auckland, Sch Biol Sci, Human Nutr Unit, Auckland, New Zealand
4.Jinan Univ, Dept Nutr, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
6.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Hematol, Guangzhou, Peoples R China
7.High Value Nutr Natl Sci Challenge, Auckland, New Zealand

Chen, Jie-Hua,Lu, Louise Weiwei,Ge, Qian,et al. Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials[J]. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION,2023,63(15).

Chen, Jie-Hua.,Lu, Louise Weiwei.,Ge, Qian.,Feng, Dana.,Yu, Jianfeng.,...&Chen, Feng.(2023).Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials.CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION,63(15).

Chen, Jie-Hua,et al."Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials".CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 63.15(2023).